甲状腺功能亢进患者PICP、ICTP和BGP等骨代谢指标水平的变化  

Variation of bone metabolism index PICP,ICTP and BGP in patients with hyperthyrea

作　　者：陈少珍[1] 黄沛隆 

机构地区：[1]广东省汕头市第二人民医院检验科,515011

出　　处：《国际检验医学杂志》2011年第12期1306-1307,共2页International Journal of Laboratory Medicine

摘　　要：目的测定甲状腺功能亢进(简称甲亢)患者骨代谢指标,探讨甲状腺激素与骨代谢的关系。方法 49例以甲亢患者为甲亢组,34例体检健康者为对照组,放射免疫法检测血清Ⅰ型前胶原羧基末端前肽(PICP)、Ⅰ型胶原羧基端吡啶并啉交联肽(ICTP)和骨钙素(BGP)、碱性磷酸酶(ALP)、总三碘甲腺原氨酸(TT3)、总甲状腺素(TT4)。结果甲亢组血清PICP、ICTP、BGP、ALP水平高于对照组(P<0.05),相关分析表明血清TT3、TT4与PICP、ICTP、BGP、ALT均呈正相关。结论甲状腺激素可直接参与骨代谢,甲亢患者骨吸收过程增加较为明显,造成骨量丢失。Objective To investigate the relationship between thyroid hormone and bone metabolism in patients with hyperthyrea.Methods Serum procollagen ⅠC-terminal propeptider（PICP）,carboxy-terminal cross linked telopeptide of type Ⅰcollagen（ICTP）,bone gla protein（BGP）,alkaline phosphatase（ALP）,total 3,5,3′-triiodothyronine（TT3）and total tetraiodothyronine（TT4）were detected in 49 patients with hyperthyrea and also 34 healthy controls.Results Serum levels of PICP,ICTP,BGP and ALP in patients group were higher than those in control group（P〈0.05）,and there were positive correlation between serum levels of TT3,TT4 and PICP,ICTP,BGP and ALP.Conclusion Thyroid hormone possible participate bone metabolism directly,and the bone formation mass might be lost as the bone absorption process obviously increase in patients with hyperthyrea

关 键 词：甲状腺功能亢进症 骨钙素 碱性磷酸酶 Ⅰ型前胶原羧基末端前肽 Ⅰ型胶原羧基端吡啶并啉交联肽 

分 类 号：R581.1[医药卫生—内分泌]