电针中脘、胃俞对大鼠胃运动及血清胃动素、胃泌素水平的影响  

Effects of Electroacupuncture at "Weishu"(BL 21) and "Zhongwan"(CV 12) on Gastric Movement and Serum Levels of Motilin and Gastrin in Rats

作　　者：王浩[1] 申国明[1] 汪克明[2] 

机构地区：[1]安徽中医学院中西医结合临床学院,安徽合肥230038 [2]安徽中医学院经脉脏腑相关研究中心,安徽合肥230038

出　　处：《安徽中医学院学报》2011年第4期37-39,共3页Journal of Anhui Traditional Chinese Medical College

基　　金：国家自然科学基金(81072871);安徽省自然科学基金(090413115)

摘　　要：目的观察电针刺激胃俞募穴对胃运动的调节是否具有协同效应,并探讨其作用机制。方法选用成年SD大鼠,随机分为空白组、中脘组、胃俞组、中脘+胃俞组。采用自制应力传感器记录各组大鼠胃窦部胃运动波形,并采用放射免疫法检测各组大鼠血清胃动素和胃泌素含量。结果与空白组相比,针刺各组胃运动幅度均明显增加(P<0.01);与中脘和胃俞组相比,中脘+胃俞组胃运动幅度显著增加(P<0.01);针刺对胃运动频率无明显影响。与空白组比较,胃俞组和中脘+胃俞组血清胃动素水平显著升高(P<0.05),胃俞组和中脘组血清胃泌素水平显著升高(P<0.05)。结论针刺胃俞募穴可明显增强大鼠胃运动,且俞募配穴法的影响更为显著,血清胃动素、胃泌素参与了电针胃俞募穴对胃运动的调节。Objective To observe whether or not there are synergistic effects of electroacupuncture（EA） at Shu-acupoint ＂Weishu＂（BL 21） combined with Mu-acupoint ＂Zhongwan＂（CV 12） in regulating gastric movement,and explore the mechanism.Methods Adult SD rats were randomly divided into control group,Zhongwan group,Weishu group,and Zhongwan plus Weishu group.The movement waves of rat gastric antrum were measured by self-made stress transducers.The serum levels of motilin and gastrin were assayed by radioimmunoassay.Results In comparision with those in the control group,the amplitudes of gastric movement were increased significantly in the three EA treated groups（P〈0.01）;and they were statistically increased in Zhongwan plus Weishu group compared with those in Zhongwan group,and Weishu group（P〈0.01）;EA had no significant effects on the frequency of gastric movement.Compared with those in the control group,the serum levels of motilin were significantly increased in Zhongwan group,and Zhongwan plus Weishu group（P〈0.05）,and the serum levels of gastrin were significantly increased in Weishu group,and Zhongwan group（P〈0.05）.Conclusion EA at ＂Weishu＂,and ＂Zhongwan＂,especially,EA at ＂Weishu＂ combined with ＂Zhongwan＂,can significantly strengthen rat gastric movement,suggesting that serum motilin and gastrin participate in regulative effects of EA at gastric Back-Shu and Front-Mu acupoints on gastric movement.

关 键 词：胃俞募穴 胃运动 胃动素 胃泌素 

分 类 号：R333[医药卫生—人体生理学] R246[医药卫生—基础医学]