叶酸和维生素B_(12)防治糖尿病肾病的研究  

Study on prevention and treatment for diabetic nephropathy with folic acid and vitamin B_(12)

作　　者：宋淑萍[1] 郭沛艳[1] 窦若兰 罗惠辛[1] 胡若梅 王娟[1] 张向英[1] 王湛[1] 魏慧芸 

机构地区：[1]天津市天和医院,天津300050

出　　处：《现代中西医结合杂志》2011年第25期3123-3125,3142,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨叶酸和维生素B12防治糖尿病肾病的作用及其机制。方法采用病例对照实验研究方法,观察糖尿病及糖尿病肾病患者经叶酸联合维生素B12治疗后血清同型半胱氨酸水平、氧化应激相关指标及24 h尿微量白蛋白等的变化。结果叶酸和维生素B12可降低糖尿病及糖尿病肾病患者血清同型半胱氨酸、丙二醛及24 h尿微量白蛋白水平,并可升高一氧化氮、超氧化物歧化酶水平。结论补充叶酸和维生素B12可作为一种早期防治糖尿病微血管并发症的新的、有效的和经济的方法。Objective It is to investigate the folic acid and vitamin B12 in the prevention and treatment for diabetic nephropathy and its mechanism.Methods A case-control study of experimental methods was used to observe the serum homocysteine levels,oxidative stress-related targets and 24h urinary albumin in patients with diabetes mellitus and diabetic nephropathy after treatment with folic acid and vitamin B12.Results Folic acid and vitamin B12 could reduce serum homocysteine,malondialdehyde（MDA） and 24h urinary albumin levels and might increase nitric oxide（NO）,superoxide dismutase（SOD） levels of patients with diabetes and diabetic nephropathy.Conclusion Adding folic acid and vitamin B12 can be a new,effective and economical method for early prevention and treatment for microvascular complications of diabetes.

关 键 词：叶酸 维生素B12 氧化应激 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]