高原青年冠心病患者血脂特点及其与冠脉病变程度的关系  

Characteristics of plasma lipid of young patients at high altitude with coronary artery disease and its relationship with severity of coronary artherosclerosis

作　　者：姜大春[1] 唐旭东[1] 尹刚[1] 虞慎也[1] 吴鹏[1] 石国芹[1] 张建蓉[1] 

机构地区：[1]解放军37医院心内科,四川雅安625000

出　　处：《西南国防医药》2011年第8期820-822,共3页Medical Journal of National Defending Forces in Southwest China

基　　金：成都军区"十一五"第二批医学科研计划课题(MB09016)

摘　　要：目的探讨高原青年冠心病(CAD)患者的血脂特点及其对冠状动脉病变的影响。方法纳入25例高原青年CAD患者和15例平原青年CAD患者,检测血脂水平,对冠状动脉造影结果进行分析和Gensini评分。结果与平原青年CAD患者比较,高原青年CAD患者血浆甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平显著升高(P<0.01或P<0.05),而高密度脂蛋白水平(HDL-C)显著降低(P<0.05)。在高原青年CAD患者中,血浆TG水平与冠脉Gensini评分呈正相关(r=0.66,95%CI:0.37～0.84,P<0.05),而血浆TC、LDL-C和HDL-C与冠脉Gensini评分无显著相关性(P>0.05)。结论高原青年CAD患者血脂异常更加严重,且血浆TG水平与冠状动脉病变程度相关。Objective To investigate the characteristics of plasma lipid of young patients at high altitude with coronary artery disease（CAD） and its effects on coronary lesions.Methods 25 young patients with CAD at high altitude and 18 ones in plain were enrolled.The levels of their plasma lipids were measured,and the severity of coronary lesions was assessed with Gensini score following coronary angiography.Results Compared with those in plain,young CAD patients at high altitude had significantly higher triglyceride（TG）,total cholesterol（TC） and low density lipoprotein-cholesterol（LDL-C）（P0.01 or P0.05） as well as lower high density lipoprotein-cholesterol（HDL-C）（P0.05）.TG level had a positive correlation with Gensini score（r=0.66,95%CI：0.37-0.84,P0.05） in CAD patients at high altitude,but TC,HDL-C and LDL-C levels did not（P0.05）.Conclusion Dyslipidemia appears to be more serious in CAD patients at high altitude.Moreover,plasma TG level is closely correlated with the severity of coronary atherosclerosis.

关 键 词：高原 青年 血脂 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]