2-芳基/脂基-5-苯基-2,3-二氢-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑的合成研究  

Synthesis of 2-aryl/alkyl-5 phenyl-2,3-dihydrogen-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles

作　　者：史海健[1] 王忠义[1] 史好新[1] 

机构地区：[1]安徽师范大学化学系,芜湖241000

出　　处：《化学试剂》1999年第6期334-336,328,共4页Chemical Reagents

基　　金：安徽省自然科学基金;安徽省教委基金资助课题

摘　　要：以 3-苯基-4-氨基-5-巯基-1,2,4-三唑为原料,在酸催化下与醛在 80℃反应 10h,合成了 12 个尚未见文献报道的标题化合物。通过元素分析、红外光谱、核磁共振氢谱和质谱确证了结构。以青霉素和庆大霉素为参比,药液浓度为0.002% 时,研究了这些化合物对金黄色葡萄球菌和大肠杆菌的抑菌作用。结果表明,有些化合物具有较强的生物活性。Twelve title compounds have been prepared by the reaction of 3 phenyl 4 amino 5 mercapto 1,2,4 triazoles with aldehyde in the presence of acid at 80℃ for 10h. The structures of these compounds have been confirmed by elemental analysis,IR, 1HNMR and MS. All the compounds were screened for antimicrobial activity against bacteria Staphylococcus aureus and Escherichia coli. The concentration of the test compounds was 0.002%. The antibacterial activities of the test compounds were compared with the standards penicillin and gentamicin. The results show that some compounds possess very strong biological activities.

关 键 词：1 2 4-三唑 1 3 4-噻二唑 合成 唑类杂环衍生物 

分 类 号：O626.2[理学—有机化学]