多沙唑嗪联合托特罗定治疗前列腺电切术后合并膀胱过度活动症的临床观察  

Clinical study of combination therapy with doxazosin and tolterodine for patients with overactive bladder after transurethral resection of the prostate

作　　者：蒋晨[1] 孙凯[1] 陈勇辉[1] 薛蔚[1] 黄翼然[1] 

机构地区：[1]上海交通大学医学院附属仁济医院泌尿科,上海200127

出　　处：《世界临床药物》2011年第8期474-477,共4页World Clinical Drug

摘　　要：目的评价多沙唑嗪联合托特罗定治疗前列腺电切术后合并膀胱过度活动症的临床疗效。方法 86例前列腺电切术(TURP)后合并膀胱过度活动症(OAB)患者随机分为多沙唑嗪组(n=46)和联合用药组(n=40),多沙唑嗪组单用多沙唑嗪缓释片一日1次4 mg,联合用药组接受多沙唑嗪和托特罗定缓释片各一日1次4 mg。评估国际前列腺症状评分(IPSS)、膀胱过度活动症症状评分(OABSS)和不良反应等。结果治疗后多沙唑嗪组IPSS和最大尿流率(Qmax)均有显著改善(P<0.05),联合用药组IPSS、储尿期症状、OABSS、OABSS问题3评分及Qmax均有显著改善(P<0.05)。联合用药组IPSS、储尿期症状、OABSS和OABSS问题3评分的改善均明显优于多沙唑嗪组,具有显著统计学意义(P<0.01)。结论托特罗定联合多沙唑嗪缓释片治疗TURP术后合并储尿期症状安全有效。Objective To evaluate the efficacy of combination therapy with doxazosin and tolterodine for patients with overactive bladder （OAB） after transurethral resection of the prostate （TURP）. Methods Totally 86 patients with OAB after TURP were randomly divided into doxazosin group （n=46） and combination group （n=40）. The patients in doxazosin group were administered with doxazosin extended release （ER） table （4 mg once daily）, and those in combination group were administered with doxazosin and tolterodine ER tablet （4 mg once daily for each）. The international prostate symptom score （IPSS）, overactive bladder symptom score （OABSS） and adverse reactions were recorded. Results The values of IPSS and Qm^x were significantly improved after treatment （P^0.05） in doxazosin group. The values of IPSS, storage IPSS, OABSS, 3ra score of OABSS and Qm^x were also significantly improved after treatment （P〈0.05） in the combination group. While the reduction of IPSS, storage IPSS, OABSS and 3rd score of OABSS in combination group was significantly greater than those in doxazosin group （P〈0.01）. Conclusion It is effective and safe for patients with OAB after TURP to accept the combination therapy with doxazosin and tolterodine ER tablets.

关 键 词：良性前列腺增生 膀胱过度活动 经尿道前列腺切除术 多沙唑嗪 托特罗定 

分 类 号：R971.9[医药卫生—药品] R969.4[医药卫生—药学]