阿奇霉素对喘息性疾病患儿免疫功能的影响  

Immunological effects of azithromycin on asthmatic children

作　　者：潘伟[1] 华亚军[1] 杨希晨[1] 刘桂华[1] 季伟[2] 

机构地区：[1]东南大学医学院附属江阴市人民医院儿科,无锡214400 [2]苏州大学附属儿童医院呼吸科,苏州215003

出　　处：《世界临床药物》2011年第8期478-481,共4页World Clinical Drug

摘　　要：目的探讨阿奇霉素对喘息性疾病患儿免疫功能的影响。方法选取毛细支气管炎、支气管哮喘和哮喘性支气管炎患儿各80例,每组随机分为干预组与未干预组,干预组在常规治疗基础上接受阿奇霉素一日10 mg/kg,共4个疗程;未干预组仅接受常规治疗。检测并比较干预组与未干预组治疗前后血清T淋巴细胞亚群及白介素(IL)-8、IL-6、肿瘤坏死因子(TNF)-α水平。结果与治疗前相比,治疗后干预组患儿血清IL-8、IL-6、TNF-α、CD4+T细胞、NK和总T淋巴细胞均降低,CD8+T细胞升高;未干预组患儿治疗前后血清T淋巴细胞亚群及细胞因子水平无显著变化。结论阿奇霉素可改善喘息性疾病患儿的免疫功能。Objective To explore the immunological effects of azithromycin on asthmatic children. Methods Totally 80 capillary bronchitis, 80 asthma and 80 asthmatic bronchitis children were selected. Every group was randomly divided into intervened group and control group. The patients in the intervened group were administered orally azithromycin 10 mg/kg once daily and common treatment, for 4 periods of treatment, and those in the control group accepted common treatment. The level of T lymphocytes subsets, IL-8, IL-6 and TNF-α before and after treatment were measured and compared. Results Compared with the data before treatment in the intervened groups, the levels of IL-8, IL-6, TNF-α, CD4＋ T cell, NK and total T cells decreased and the level of CD8＋ T cell increased after treatment. However, the levels ofT cell subsets and cytokines had no significant differences between the data before and after treatment in the control group. Conclusion Azithromycin may improve the immunity for the children with asthmatic diseases.

关 键 词：阿奇霉素 喘息性疾病 淋巴细胞 细胞因子 

分 类 号：R978.15[医药卫生—药品] R562[医药卫生—药学]