双苯氟嗪盐酸盐和苯甲酸的共晶制备和谱学分析  

Synthesis and Spectral Characteristic of Pharmaceutical Dipfluzine Hydrochloride-Benzoic Acid Co-Crystal

作　　者：杨彩琴[1] 王静[1] 张振伟[2] 

机构地区：[1]河北医科大学药学院,河北石家庄050017 [2]北京市太赫兹谱重点实验室,首都师范大学物理学院,北京100048

出　　处：《光谱学与光谱分析》2011年第9期2476-2479,共4页Spectroscopy and Spectral Analysis

基　　金：国家(973计划)研究项目(2007CB310408);河北省自然科学基金项目(2008001072);河北省教育厅科学基金项目(2009148);河北省卫生厅基金项目(20090059)资助

摘　　要：药物共晶是改善药物活性成分(API)的物理化学特性的新技术和新思维,具有很大的应用潜力。本实验采用研磨法制备了双苯氟嗪盐酸盐(DF-HCl)和苯甲酸的共晶,应用红外光谱(IR)、拉曼光谱(Raman)、差示扫描量热分析(DSC)、X射线衍射(XRD)和太赫兹光谱(THz)对共晶进行了表征。结果表明:双苯氟嗪盐酸盐与苯甲酸之间形成共晶分子,太赫兹谱的研究进一步表明两种分子之间有氢键形成。Pharmaceutical co-crystals can improve the chemical and physical properties of active pharmaceutical ingredient （API）, which is new idea and expected to provide new stable structures. Pharmaceutical co-crystals have the potential to be much more useful in pharmaceutical products than salts, solvates or hydrates, polymorphs and stoichiometric solvates （pseudo- polymorphs）. In our study, dipfluzine hydrochloridc-benzoic acid co-crystal was synthesized by solid co-grinding. The samples were subjected to IR, DSC, XRD, Raman and THz spectral analysis. The results indicated that dipfluzine hydrochloride-benzoic acid complex was new phase compared with the single API and CCF. THz-TDS characterization indicated that hydrogen bond formed between API and CCF, which confirmed the formation of co-crystal.

关 键 词：药物活性成分 红外光谱 拉曼光谱 太赫兹光谱 共晶 

分 类 号：R943[医药卫生—药剂学] R972[医药卫生—药学]