中药分期治疗对兔桡骨骨折延迟愈合X线及血清ALP的影响  

Impact of Chinese Medicine Treatment per Fracture Phase on X ray Score and ALP in Fractured Rabbits

作　　者：李天朗 唐志宇[2] 王祖祥[1] 付勇[1] 温月[1] 

机构地区：[1]四川省德昌县人民医院 [2]广州中医药大学

出　　处：《世界中医药》2011年第4期347-348,共2页World Chinese Medicine

摘　　要：目的:观察中药分期治疗对兔骨折延迟愈合X线及血清碱性磷酸酶(ALP)的影响。方法:新西兰兔75只,无菌术下左侧桡骨中下1/3切除10mm后,除模型组外其余4组髓腔用骨腊封闭,分为治疗1组、治疗2组、治疗3组、模型组、延迟愈合模型组,每组15只。其中治疗2组术后按骨折分期第2天开始给药,治疗3组和治疗1组4周成模后给药,延迟愈合模型组和模型组术后第2天灌等容量的生理盐水,延迟愈合模型组成模后骨延迟愈合区注入自体红骨髓。术后第4周和8周检测血清ALP和拍摄线片。结果:第4周治疗2组血清ALP明显高于其他4组,差异极显著(P<0.01),第8周与延迟愈合模型组比较差异极显著(P<0.01),与模型组比较差异显著(P<0.05),治疗1组和治疗3组血清ALP与模型组比较显著下降(P<0.05),与治疗2组比较无显著性差异(P>0.05)。第4周末X线肉眼评分模型组极显著高于其他各组,第8周末治疗2组肉眼评分显著高于治疗1组和治疗3组及延迟愈合模型组(P<0.01),与模型组无明显差异(P>0.05)。结论:中药分期治疗明显提高了骨折X线肉眼评分,治疗2组血清ALP明显提高,中药组均有促进骨折愈合的作用。Objective：To investigate impact of Chinese medicine treatment per phase on X ray film and serum ALP level in fractured rabbits.Methods：75 New zealand rabbits with fracture were equally divided to treatment group 1 to 3,model group （group 4） and delay union group（group 5）.From Day2,group 2 was administered with Chinese medicine per fracture phase,group 4 and group 5 received same volume physiological saline,from Week4 group 1 and group 3 began treatment.Delay union group was injected with red marrow after establishment of modeling.At Week4 and Week8 following operation,serum ALP and X ray film were taken.Results：At Week4 ALP level of group2 was significantly higher than that of the rest groups （P〈0.01）,and kept at significant higher level in comparison with the model group and delay union group at Week 8.There wasn＇t significant ALT difference between group 1 and group 2.At Week4 the model group had the highest score per X ray film,at Week8 the score of group2,higher than other groups,was not significantly different with the score of model group.Conclusion：Chinese medicine treatment per fracture phase can significant increase X-ray score and serum ALP level.The groups given Chinese medicine treatment can improve union of fracture.

关 键 词：中药分期 骨折延迟愈合 X线 ALP 

分 类 号：R681[医药卫生—骨科学]