叶酸和维生素B_12对糖尿病患者同型半胱氨酸和氧化应激水平的影响  

THE EFFECT OF FOLIC ACID AND VITAMIN B_12 ON THE LEVELS OF THE HOMOCYSTEINE AND THE OXIDATIVE STRESS IN PATIENTS WITH DIABETES

作　　者：郭沛艳[1] 宋淑萍[1] 罗惠辛[1] 窦若兰 王娟[1] 张向英[1] 胡若梅 王湛[1] 魏慧芸 

机构地区：[1]天津市天和医院,天津300050

出　　处：《现代预防医学》2011年第16期3184-3186,共3页Modern Preventive Medicine

摘　　要：[目的]探讨叶酸和维生素B12在防治糖尿病的作用及其作用机理。[方法]采用病例对照实验研究方法,观察糖尿病患者叶酸联合维生素B12治疗后血清同型半胱氨酸水平、氧化应激相关指标等的影响。[结果]该治疗可降低糖尿病患者血清同型半胱氨酸、丙二醛(MDA)水平,并可升高一氧化氮(NO)、超氧化物歧化酶(SOD)水平。[结论]叶酸联合维生素B12干预后,糖尿病患者同型半胱氨酸水平降低,氧化应激状态改善,因此补充叶酸和维生素B12可成为一种早期防治糖尿病的新的、有效的和经济的方法。[Objective]To investigate the use of folic acid and vitamin B12 in the prevention and treatment of diabetes and its mechanism.[Methods]Through case-control study,we observed the change of the serum homo-cysteine levels and oxidative stress-related indicators after treatment using folic acid combined with vitamin B12 in patients with diabetes.[Results]This treatment for diabetic patients could reduce serum homocysteine and malondialdehyde（MDA）levels,and increase nitric oxide（NO）,superoxide dismutase（SOD）levels.[Conclusion]Folate and Vitamin B12 intervention can reduce the homocysteine levels of diabetics and improve the oxidative stress,so folic acid and vitamin B12 intervention can be an new,effective and economical way in early prevention of diabetes.

关 键 词：叶酸 维生素B12 氧化应激 糖尿病 

分 类 号：R587.1[医药卫生—内分泌] R977.22[医药卫生—内科学]