血清及支气管肺泡灌洗液中细胞因子在急性呼吸窘迫综合症中的意义  

SERUM AND BRONCHOALVEOLAR LAVAGE FLUID CYTOKINES IN ACUTE RESPIRATORY DISTRESS SYNDROME IN THE SENSE

作　　者：张晓调[1] 

机构地区：[1]温州医学院附属第三医院,瑞安325200

出　　处：《现代预防医学》2011年第16期3383-3384,3389,共3页Modern Preventive Medicine

摘　　要：[目的]探讨血清及支气管肺泡灌洗液中细胞因子IL-8、IL-6及其受体IL-6R在急性呼吸窘迫综合症中的意义。[方法]连续纳入入住我院呼吸内科病房患者45人,分为3组:甲组:ARDS患者,乙组:有ARDS高危因素48h内发生ARDS,丙组:有ARDS高危因素但未发生ARDS。测量每个病人血浆及肺泡灌洗液中上述各细胞因子浓度,并比较3组间的差异。[结果]甲组肺泡灌洗液中的IL-6r浓度显著高于乙组及丙组(188±61vs.89±29和80±26;P﹤0.05),而乙组肺泡灌洗液中的IL-6浓度高于甲组及丙组(1130±998vs.313±22和531±401;P﹤0.05)。而血浆中的各种细胞因子在3组中未见明显差异。[结论]IL-6在ARDS发生的早期起重要的作用,可能是早期的一个启动因子,而IL-8在人类ARDS中的作用尚需进一步研究。[Objective]To investigate the serum and bronchoalveolar lavage fluid cytokines IL-8,IL-6 and its receptor IL-6R in patients with acute respiratory distress syndrome in significance.[Methods]Consecutive into the respiratory medical ward of our hospital stay 45 patients were divided into three groups：Group A：ARDS patients,Group B：There are risk factors for ARDS within 48 hours of ARDS,and Group C：There are risk factors for ARDS but did not happen ARDS. The concentrations of the above cytokines in the plasma and bronchoalveolar lavage fluid of each patient were measured and the difference between the three groups.[Results]The concentrations of cytokines in the plasma and bronchoalveolar lavage fluid of the three groups were showed in Table 2,where BALF IL-6r in the Group A was significantly higher than that of Group B and Group C（188 ± 61 vs. 89 ± 29 and 80 ± 26;P﹤0.05）,while BALF IL-6 concentrations of Group B in were higher than Group A and Group C（1130 ± 998 vs. 313 ± 22 and 531 ± 401;P﹤0.05）. The plasma in a variety of cytokines in the three groups showed no significant difference.[Conclusion]IL-6 in ARDS in the early stage plays an important role,possibly an early initiation factor,and IL-8’s role in human ARDS requires further study concluded.

关 键 词：细胞因子 急性呼吸窘迫综合症 肺泡灌洗液 IL-6 IL-8 

分 类 号：R563.8[医药卫生—呼吸系统]