辛伐他汀对高血压病患者血浆肾上腺髓质素的作用  

Effect of simvastatin on plasma level of adrenmedullin in patients with hypertension

作　　者：张润峰[1] 刘建蓉[1] 

机构地区：[1]绵阳市第三人民医院心血管内科,621000

出　　处：《健康必读（下）》2011年第8期37-37,共1页

摘　　要：目的：探讨辛伐他汀对高血压病患者血浆肾上腺髓质素水平的影响作用。方法60例高血压痛患者，随机分为辛伐他汀组和对照组，各30例。对照组给予左旋氨氯地平2．5mg，每日1次；辛伐他汀组在服用同样剂量左旋氨氯地平基础上，每晚睡前给予辛伐他汀20mg口服，疗程4周。两组患者于基线时和4周后应用放射免疫方法检测患者血浆肾上腺髓质素水平；并测量血压。结果基线时，两组患者血压与血浆肾上腺髓质素均无显著性差异（P〉0.05）。4周后与对照组比较，辛伐他汀组患者血压下降显著（P〈0．05），血浆肾上腺髓质素水平显著升高（P〈0．05）。结论辛伐他汀对高血压痛患者具有降血压、升高血浆肾上腺髓质素水平作用；肾上腺髓质素可能参与辛伐他汀降血压作用。Objective We investigated the effect of simvastatin on adrenmedullin （ADM） levels in patients with hypertension. Methods Sixty essential hypertension patients were randomized in a 1 ： 1 ratio to simvastatin group and control group. All patients were treated with Levamlodipine 2.5mg once a day ; the patients in the simvastatin group were treated with simvastatin 20mg in addition. Simvastatin was taken at bed -time. Blood pressure was measured, the levels of ADM were assessed by radio - immunoassay at baseline and 4 weeks＇follow - up. Results At baseline, there were no significant difference for blood pressure and plasma levels of ADM between two groups. Compared with control group after 4 weeks, blood pressure was decreased （P 〈 0.05 ）, and the plasma levels of ADM were significant increased in the simvastatin group（ P 〈 0. 05）. Conclusion Simvastatin could lower blood pressure and increase the levels of ADM in patients with essential hypertension. Our results suggested ADM may play an impertant role for simvastatin preventing the increase of blood pressure in patient with hypertension.

关 键 词：辛伐他汀 肾上腺髓质素 高血压 

分 类 号：R684[医药卫生—骨科学]