文冠果的化学成分与生物活性研究进展  

Advances in study on chemical and biological activity of Xanthoceras sorbifolia

作　　者：王颖[1] 姜生 孟大利[1] 李宁[1] 

机构地区：[1]沈阳药科大学中药学院基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016 [2]黑龙江省美东尿控药物研究中心,黑龙江哈尔滨150086

出　　处：《现代药物与临床》2011年第4期269-273,共5页Drugs & Clinic

基　　金：国家科技重大专项(2009ZX09501-011)

摘　　要：文冠果为我国特有的珍稀木本油料作物,是绿化、食用、药用和制作生物燃料油的重要木本油料树种,近年来广泛受到学术界关注。其果仁、果皮、枝叶等药用部位富含三萜、黄酮、香豆素、甾醇等化学成分。现代医学研究表明,文冠果具有抗炎、抗肿瘤、抑制HIV蛋白酶、促进NGF介导的神经突触生长、改善学习记忆等药理作用和生物活性。对近年来有关文冠果不同药用部位的化学成分、生物活性、检测方法等方面的研究进展进行了综述。Xanthoceras sorbifolia is one of rare and precious woody oil crops in China, which has been paid extensive attention in recent years for the use in green, edible, medicinal, and making bio-fuel purpose. Its nut, peel, branch, and leaves are rich in many kinds of chemical compositions, such as triterpenes, flavonoids, coumarins, sterols, and so on. Modern medicinal research shows that X. sorbifolia has the pharmacological and biological activity of anti-inflammation, anti-cancer, inhibiting HIV protease, and improving learning in mind. This article is based on the chemical composition in different medicinal parts of X. sorbifolia, biological activity, and the detection method.

关 键 词：文冠果 三萜类 黄酮类 文冠果皂苷 抗炎 抑制HIV蛋白酶 

分 类 号：R282.71[医药卫生—中药学]