清脑降压滴丸的制备  

Preparation of Qingnao Jiangya Dropping Pills

作　　者：郑雅楠[1] 吕沅珊[2] 吴疆[1] 任涛[1] 

机构地区：[1]天津药物研究院,天津300193 [2]天津市南开医院天津市中西医结合急腹症研究所,天津300100

出　　处：《现代药物与临床》2011年第4期299-301,共3页Drugs & Clinic

摘　　要：目的研究影响清脑降压滴丸成型的因素,确定最佳制备工艺。方法通过单因素筛选和正交试验设计,进行清脑降压滴丸的制备工艺条件的研究。结果优选的最佳成型工艺为药物与基质配比为1:2、基质为聚乙二醇6000、滴制温度为75℃、冷却液温度为10℃。结论优选的清脑降压滴丸成型工艺简便易行,成品得率高,丸质量差异、崩解时限符合要求。Objective To optimize the technical parameters on Qingnao Jiangya Dropping Pills. Methods To investigate the preparation technique and optimal formulation of Qingnao Jiangya Dropping Pills based on the studies of influential factors, optimal formulation was obtained by the orthogonal design. Results The optimum molding parameters were as follows： the ratio between drug and matrix was 1∶2, matrix was PEG 6000, dropping temperature was 75 ℃, the cooling fluid temperature was 10 ℃. Conclusion The optimization of the molding process is simple, high-yield, and the weight deviation and the disintegration time conform to the standard.

关 键 词：清脑降压滴丸 制备 聚乙二醇6000 正交试验 

分 类 号：R283.6[医药卫生—中药学]