低砷暴露人群内外暴露指标间的相关性研究  

Study on the relationships between external and internal exposure biomarkers of arsenic

作　　者：张敏[1] 胡晓抒 刘湘玲[3] 向全永[4] 

机构地区：[1]江苏省计划生育科学技术研究所流病中心,江苏南京210036 [2]江苏省卫生厅 [3]东南大学公共卫生学院 [4]江苏省疾病预防控制中心慢病防治所

出　　处：《中国地方病防治》2011年第4期247-249,共3页Chinese Journal of Control of Endemic Diseases

基　　金：江苏省卫生厅2005年血地寄防应用性科研课题(X200529)

摘　　要：目的了解低砷暴露人群的内外暴露指标之间的关系。方法从低砷暴露地区随机抽取250户家庭,收集家庭手压井的饮用水,用原子荧光光度法测定水中砷含量。用KISH表法从每户家庭中随机抽取1名30岁以上调查对象,用调查表收集被调查对象的基本情况,如年龄、性别、生活习惯和家庭收入等。并收集调查对象的空腹血样及首次晨尿,利用氢化物发生-冷井捕集-原子吸收分光光度计法测定尿液及血清中的总砷、无机砷、一甲基砷酸、二甲基砷酸含量。结果水砷含量、尿中总砷含量以及血清中总砷含量存在正相关(P<0.05),单因素以及多因素分析均发现,尿中总砷含量、砷甲基化代谢产物均随着水砷含量的增加而增加(P<0.01)。结论水砷、尿砷及尿中的砷甲基化代谢产物可作为低砷暴露人群的敏感指标。Objective To explore the relationships between external and internal exposure biomarkers of arsenic.Methods 250 families were random collected from the village with lower level of arsenic in drinking water.The samples of drinking water were collected from the household shallow well and the arsenic was detected by atomic fluorophotometer.The random method of KISH was used to select a subject（30 year old） from each family for our study.The basically information（such as age,sex,lifestyle,family income,and so on） of the subjects were surveyed using questionnaires.Fasting venous blood and first urina sanguinis were taken from each subject.Inorganic arsenic（iAs）,monomethylated arsenic（MMA）,and dimethylated arsenic（DMA） in serum and urine were detected using the methods of cold trap hydride generation-atomic absorption spectrometry（HG-AFS）.Results The correlation analysis indicated that the arsenic in the water had a positive correlation with total arsenic in urine（TAsu）,total arsenic in serum（TAsb）.After adjusted age and gender using multiple linear regressions,the iAs,MMA,DMA in the urine was increased with the increasing of arsenic in the water.Conclusion Arsenic in drinking water,arsenic and its products of methylation in urine are the sensitively exposure biomarkers of arsenic for the exposure subjects with lower level arsenic in their drinking water.

关 键 词：地方性砷中毒 水砷 甲基化 

分 类 号：R599.9[医药卫生—内科学]