血清25-(OH)D_3 TIgE水平与儿童支气管哮喘相关性研究  

The Study of Relationship Between the Serum Levels of 25-(OH)D3, TIgE and Children Bronchial Asthma

作　　者：甄艳芬[1] 马秀丽[1] 

机构地区：[1]中国人民解放军第253医院儿科,内蒙古呼和浩特010051

出　　处：《内蒙古医学杂志》2011年第5期538-540,共3页Inner Mongolia Medical Journal

摘　　要：目的:通过测定儿童支气管哮喘血清25-羟维生素D3(25-(OH)D3)、总免疫球蛋白E(TIgE)含量并与正常儿童相对照,以探讨儿童支气管哮喘的发病与血清25-(OH)D3及TIgE之间的关系。方法:采用放射免疫分析法(RIA),检测儿童支气管哮喘30例及正常对照儿童40例血清中25-(OH)D3、TIgE含量,比较两组之间血清浓度的变化。结果:支气管哮喘组血清25-(OH)D3含量明显低于正常对照组,两组比较差异具有统计学意义(t=40.201,P=0.000);支气管哮喘组血清TIgE含量明显高于正常对照组,两组比较差异具有统计学意义(t=20.048,P=0.000);支气管哮喘组血清25-(OH)D3含量与TIgE含量存在相关性,呈负相关(r=-0.783,P=0.000),正常对照组血清25-(OH)D3含量与TIgE含量无相关性(r=-0.047,P=0.774)。结论:血清25-(OH)D3的缺乏可能是导致儿童支气管哮喘发生发展的重要原因;支气管哮喘组血清25-(OH)D3与TIgE有明显的负相关性,表明儿童支气管哮喘与变态反应密切相关,提高血清25-(OH)D3浓度或许可以预防并治疗儿童支气管哮喘。Objective：To measure the serum levels of 25-（OH） D3 and TIgE in the children who had bronchial asthma and compared with the healthy children.To investigate the associations between children bronchial asthma and the serum levels of 25-（OH） D3 and TIgE.Methods：30 cases of childhood bronchial asthma were involved and 40 cases of healthy children as the controls.Double-antibody radioimmunoassay（RIA） was used to detect the levels of serum 25-（OH）D3 and TIgE.Results：The level of serum 25-（OH）D3 in the children who had bronchial asthma was significantly lower than that in the healthy controls,the difference was highly statistically significant（t=40.201,P=0.000）;The level of serum total IgE was obviously higher in the bronchial asthma group than that in the healthy control group,the difference was highly statistically significant（t=20.048,P=0.000）;The significant correlation between the level of serum 25-（OH）D3 and TIgE was observed in the children who had asthma（r=-0.970,P0.001）,There was no significant correlation in the control group（r=-0.047,P=0.774）.Conclusion：The serum levels of 25-（OH）D3 may be associated with childhood bronchial asthma.The significant negative correlations between the levels of 25-（OH）D3 and TIgE in the children who had bronchial asthma indicates that bronchial asthma has a close relationship with the allergy.Through increasing the concentration of 25-（OH）D3 may prevent or treat childhood bronchial asthma.

关 键 词：支气管哮喘 25-羟维生素D3 总免疫球蛋白E 儿童 

分 类 号：R725.6[医药卫生—儿科]