泌尿生殖道分泌物淋病奈瑟菌耐药性分析  

Drug Resistance Analysis of Genitourinary Tract Secretion Neisseria Gonorrheae

作　　者：常改凤[1] 赖玉华[1] 刘志伟[1] 周小合[1] 余高冰[1] 陈灿锋[1] 罗俊生[1] 

机构地区：[1]广东省深圳市宝安区西乡人民医院,518102

出　　处：《职业与健康》2011年第15期1727-1728,共2页Occupation and Health

摘　　要：目的了解深圳市宝安区部分地区患者泌尿生殖道分泌物淋病奈瑟菌感染性别差异及耐药谱,分析耐药菌株的流行特点,为临床制定合理用药方案提供依据。方法淋病奈瑟菌采用TM选择性培养基进行分离鉴定,药敏结果采用K-B法。结果 219例淋病患者中男性女性感染率分别为22.80%、5.40%,其对氟喹诺酮类和四环素耐药率均达80%以上,对青霉素耐药率为72.60%,对头孢曲松、头孢噻肟和大观霉素的耐药率分别为10.05%、13.47%和2.74%,未发现对头孢西丁耐药菌株。结论淋病奈瑟菌对大观霉素和头孢西丁的敏感性较高,可作为医生凭经验治疗的首选药物,对青霉素、四环素和环丙沙星高水平耐药,尽量少用以提高疗效和减少耐药菌株的产生。[Objective]To understand the gender differences of patients with genitourinary tract secretion neisseria gonorrheae and the drug resistance of neisseria gonorrheae,to analyze the epidemic characteristics of drug-resistant strains,and provide evidence for rational drug use in clinic.[Methods]TM selective medium was adopted for neisseria gonorrheae separation of identification,Drug susceptibility adopted K-B method.[Results]Of 219 cases of gonorrhea infection,male and female infection rate was 22.80%,5.40%,respectively.Its resistance to fluoroquinolones and tetracycline was above 80%,72.60% for Penicillin,10.05% for ceftriaxone,13.47% for cefotaxime and 2.74% for spectinomycin.While drug-resistant strains to cefoxitin were not found.[Conclusion]Neisseria gonorrheae is highly sensitive to spectinomycin and cefoxitin which can be taken as first choice for clinical use by doctors＇ experiences.It is highly resistant to penicillin,tetracycline and ciprofloxacin.Therefore,these antibiotics should be used as little as possible to reduce the generation of drug-resistant strains.

关 键 词：分泌物 淋病奈瑟菌 抗菌药物 耐药性 

分 类 号：R117[医药卫生—公共卫生与预防医学]