生酮饮食对兔心肌缺血再灌注损伤的保护  

Protective Function of KD on Myocardial Ischemia-reperfusion Injury in Rabbit

作　　者：刘志强[1] 崔利德[1] 

机构地区：[1]济宁医学院人体解剖教研室,山东省日照市276826

出　　处：《职业与健康》2011年第15期1736-1737,共2页Occupation and Health

摘　　要：目的探讨生酮饮食(KD)对兔心肌缺血再灌注损伤影响。方法分别给予雄性兔正常饮食(normal diet,ND)和KD6周后,结扎免冠状动脉左前降支30 min后,恢复再灌注180 min,通过观察心电图、心肌酶学和心肌梗死范围指标,评价KD对兔心肌缺血再灌注损伤的保护作用。结果 A组(ND+假手术组)乳酸脱氢酸、肌酸激酶活力未升高,心电图无变化,心肌无梗死。B组(ND+缺血再灌注组)变化明显。C组(KD+缺血再灌注组)较B组轻。结论用KD干预后,兔心肌缺血再灌注损伤减轻。[Objective]To discuss the effect of Ketogenic diet（KD） on myocardial ischemia-reperfusion injury in rabbit.[Methods]After pretreatment normal diet（ND） and KD respectively in male rabbits for 6 weeks,all the rabbits were ligated with the left anterior descending coronary arteries for 30 min and then recovered reperfusion for 180 min.The protection of KD on myocardial ischemia-reperfusion injury was evaluated by monitoring of ECG and serum creatine kinases,and myocardial infarct size measurements.[Results]In Group A（ND＋ sham operation） LDH,CK is not elevated,without change in ECG and myocardial infarction.In Group B（ND ＋ ischemia-reperfusion）,the changes were significant.The injury of Group C（KD ＋ ischemia-reperfusion） was lighter than that of Group B.[Conclusion]KD intervention relives the ischemia-reperfusion injury.

关 键 词：生酮饮食 缺血再灌注损伤 兔 

分 类 号：R965[医药卫生—药理学]