苯乙炔树枝状化合物制备中的Sonogashira和Glaser偶联反应  

Sonogashira and Glaser coupling reaction in the synthesis of phenylacetylene dendrimers

作　　者：何振华[1] 钟汉斌[1] 陈秋燕[1] 王成云[1] 沈永嘉[1] 

机构地区：[1]华东理工大学结构可控先进功能材料及其制备教育部重点实验室,上海200237

出　　处：《中国科技论文在线》2011年第6期439-442,共4页

基　　金：高等学校博士学科点专项科研基金资助项目(20070251018);国家自然科学基金资助项目(20872035;21076078)

摘　　要：以4-叔丁基苯乙炔和三溴苯为最初原料,合成了多种苯乙炔树枝状化合物,用1H-NMR、MS等表征手段确证了苯乙炔树枝状化合物的结构,并研究了影响反应的一些因素。研究结果表明,Sonogashira和Glaser偶联反应是一对竞争性反应,在通过Sonogashira偶联反应合成苯乙炔树枝状化合物时,时常伴随着Glaser偶联反应的发生和副产物的生成,为了减少Glaser偶联反应副产物的生成,必须使用新制备的催化剂,反应体系必须严格去氧。Several phenylacetylene dendrimers have been synthesized,with the 4-tert-butyl-phenylacetylene and 1,3,5-tribromobenzene as raw materials,and their structure were confirmed by 1H-NMR and MS.Some factors affecting the reaction were also studied.The results showed that Sonogashira coupling and Glaser coupling are a pair of competitive reactions.Glaser coupling maybe occurred and formed by-products in the synthesis of phenylacetylene dendrimers through Sonogashira coupling.In order to decrease the by-products formed by Glaser coupling,new prepared catalyst and rigorous deoxygenation are necessary.

关 键 词：合成 树枝状化合物 SONOGASHIRA偶联反应 Glaser偶联反应 

分 类 号：TQ203.2[化学工程—有机化工]