青藤碱A环衍生物的合成  

Synthesis of Sinomenine Derivatives on Ring A

作　　者：郑兴良[1] 张宏志[2] 蒋宁飞[1] 陈淑君[1] 欧阳玲玲[1] 

机构地区：[1]长沙理工大学化学与生物工程学院,中国长沙410114 [2]玉林师范学院化学系,中国玉林53700

出　　处：《湖南师范大学自然科学学报》2011年第4期59-63,共5页Journal of Natural Science of Hunan Normal University

基　　金：国家自然科学基金资助项目(20976017);湖南省长沙市科技局重点资助项目(K1101022-11)

摘　　要：以青藤碱、芳香醇或脂肪醇作为反应物,在三苯基磷(PPh3)和偶氮二甲酸二乙酯(DEAD)的促进下,合成了7个青藤碱A环衍生物,并利用1H NMR,13C NMR,MS和元素分析对目标化合物的结构进行了表征,在以THF作溶剂,室温的温和反应条件下,收率达到78%～94%,这种合成方法简单,条件温和,选择性好,能够广泛地应用于多官能团天然产物的结构修饰中.Seven sinomenine derivatives on ring A were synthesized using sinomenine and benzyl alcohol or aliphatic alcohol as reactants, and triphenylphosphine （PPh3） and diethyl azodicarboxylate （DEAD） as dehydrating agent. The structure of target compounds were characterized by ^1 H NMR, ^13C NMR, MS spectra and elemental analysis. The yield can amount to 78% -94% under the optimized reaction condition involving THF as solvent and room temperature. The synthesis method is simple and the reaction conditions are mild with excellent target product selectivity as well. It may be widely used as modifying natural products with multifunctional groups.

关 键 词：青藤碱 衍生物 三苯基膦 偶氮二甲酸二乙酯 

分 类 号：O626.24[理学—有机化学]