哈蟆油非水溶性成分抗疲劳保健功能研究  

Study on Anti-fatigue Function of Non-Water-Soluble Components of OVIDUCTUS RANAE

作　　者：王涵[1] 赵雨[1] 张梅[1] 幺宝金[2] 张鑫[1] 

机构地区：[1]长春中医药大学中医药与生物工程研发中心,吉林长春130117 [2]吉林大学公共卫生学院,吉林长春130021

出　　处：《安徽农业科学》2011年第20期12233-12234,12271,共3页Journal of Anhui Agricultural Sciences

基　　金：国家"十一五"科技支撑项目(2007BAI38B06)

摘　　要：[目的]研究哈蟆油(OVIDVCTUS RANAE)非水溶性成分的抗疲劳作用。[方法]以低、中、高(0.25、0.5、1.0 g/kg)3个剂量的哈蟆油非水溶性成分连续灌胃小鼠30 d,空白对照组给予等量的蒸馏水,测定小鼠负重游泳时间、血清尿素、肝糖原和血乳酸含量。[结果]哈蟆油非水溶性成分中剂量组小鼠的游泳时间明显长于对照组(P<0.05);各剂量组小鼠肝糖原含量均明显高于对照组(P<0.05);中、高剂量组小鼠运动后的血乳酸曲线下面积均小于对照组(P<0.05);各剂量组小鼠运动后血清尿素氮含量无明显改变。[结论]哈蟆油非水溶性成分具有抗疲劳作用。[Objective] The aim was to study the anti-fatigue effect of the non-water-soluble components of OVIDUCTUS RANAE.[Methods] The mice were divided into the low,medium and high dose groups and negative control group at random.Weight loaded swimming time,urea nitrogen,hepatic glycogen content,blood lactate were determined after giving test substances by intragastrical gavage for 30 days.[Results] The non-water-soluble components of OVIDUCTUS RANAE in medium dose groups obviously prolonged small mice swimming time（P0.05）.Each group can made hepatic glycogen obviously improved and compared with blank observe group,it had obvious differences（P0.05）.Middle and high dose groups after exercise,blood lactic area under the curve was less than the control group（P0.05）.[Conclusion]The non-water-soluble components of OVIDUCTUS RANAE had the function of anti-fatigue.

关 键 词：哈蟆油 非水溶性成分 抗疲劳 

分 类 号：R961.1[医药卫生—药理学]