肝癌动物模型的研究及进展  

Research Progress in Animal Models of Liver Cancer

作　　者：申凤鸽[1] 

机构地区：[1]吉林大学人兽共患病研究所,吉林长春130062

出　　处：《安徽农业科学》2011年第20期12264-12266,共3页Journal of Anhui Agricultural Sciences

摘　　要：[目的]建立良好的肝癌动物模型,为人类治疗肝癌服务。[方法]简单介绍几种比较常见的肝癌动物模型。[结果]目前比较常用的动物模型有:Hepa1-6细胞诱发C57BL/6J小鼠原位肝癌模型、采用Hep_G2细胞株建立裸鼠肝癌模型、直接移植法建立大鼠肝癌模型、直接注入法建立大鼠肝癌模型、免疫重建荷人高转移肝癌SCD鼠模型、其他移植性肝癌模型和基因性肝癌模型。[结论]动物模型是进行试验研究的重要手段和平台,建立肝癌动物模型对肝癌发生机制、诊断与治疗研究有很重要的意义。[Objective] To establish good animal models of liver cancer and serve treatment of liver cancer in humans.[Method] Several common animal models of liver cancer were introduced briefly.[Result] The commonly used animal models include C57BL/6J mouse model of orthotopic liver cancer induced with Hepa1-6 cells,nude mouse model of liver cancer established with Hep_G2 cell lines,rat liver cancer model established through direct transplantation or direct injection,HU-PBL-SCID mice model,and other transplanted liver cancer models or genetic liver cancer models.[Conclusion] Animal model is an important means and platform for experimental studies.To establish animal models of liver cancer is of important significance for studies on pathogenesis,diagnosis and treatment of liver cancer.

关 键 词：肝癌 动物模型 

分 类 号：S858[农业科学—临床兽医学]