莫西沙星引起QT间期异常延长  

Abnormal QT interval prolongation associated with moxifloxacin

作　　者：郑策[1] 甄健存[1] 

机构地区：[1]北京积水潭医院药剂科,北京100035

出　　处：《中国药物应用与监测》2011年第4期257-258,共2页Chinese Journal of Drug Application and Monitoring

摘　　要：1例87岁男性患者,房颤、冠心病史20余年,因怀疑肺部感染静脉用莫西沙星400 mg,qd。次日,患者出现胸闷、头晕,心电图显示QTc 489 ms,较入院时的435 ms延长了54 ms。立即停用莫西沙星,8 h后,QTc 442 ms,接近入院时水平,以后均未有异常改变。One 87-year-old man with a history of atrial fibrillation and coronary heart disease for more than 20 years, was intravenously given 400 mg of moxifloxacin once daily for suspected lung infection. On the second day of moxifloxacin administration, the patient developed dyspnea and dizziness, and electrocardiogram showed prolongation of the QTc interval to 489 ms, which was 54 ms longer than the value at the time of admission （435 ms）. Moxifloxacin was promptly withdrawn. Eight hours later, the QTc interval was 442 ms, which was close to the baseline range, and had no abnormal change during the therapy time.

关 键 词：莫西沙星 QT间期延长 药品不良反应 

分 类 号：R595.3[医药卫生—内科学]