嗜酸性蜂窝织炎  

Eosinophilic cellulitis:a case report

作　　者：余婷婷[1,2] 闵仲生[3] 谭诚[3] 朱宁 

机构地区：[1]南京中医药大学第一临床医学院,江苏南京210029 [2]苏州市吴中皮肤病医院,苏州215000 [3]江苏省中医院皮肤科,江苏南京210029 [4]南京市江宁区中医院皮肤科,江苏南京211100

出　　处：《临床皮肤科杂志》2011年第9期567-569,共3页Journal of Clinical Dermatology

摘　　要：报告1例嗜酸I生蜂窝织炎。患者男，36岁。双下肢红斑时有痒痛半个月。外周血嗜酸性粒细胞2．55×10^9L（分类0．263），骨髓嗜酸f生粒细胞0．125，FIP1L1／PDGFRα融合基因（-），骨髓组织病理示嗜酸性粒细胞相对增生活跃。皮损组织病理检查：真皮及皮下组织浅层小血管内皮细胞肿胀，不同程度纤维素样变性、坏死直至阻塞，周围见大量嗜酸性粒细胞反应性浸润，呈火焰状，其间有少量淋巴细胞。诊断：嗜酸性蜂窝织炎。予甲泼尼龙和抗组胺药等治疗后皮损消退。A 36-year-old male with eosinophilic cellulitis is reported. The chief complaint was painful and itchy patches on the lower limbs for half a month. Eosinophilia was found both in the peripheral blood and bone marrow, and eosinophils were 2.55×10^9/L （0.263）and 0.125 respectively. Bone marrow biopsy showed that eosinophils proliferated actively, but the FIP1L1/PDGFR alpha fusion gene was negative. Histological findings of the skin lesion revealed that endothelial swelling of small vessels in the dermis and superficial subcutaneous tissue, and fibrinoid degeneration up to necrosis with surrounding massive eosinophils and a few lymphocyte infiltration, which looked like ＂flame images＂. The diagnosis was made as eosinophilic cellulitis, and the skin lesions improved after treatment with methylprednisolone and antihistamine for 3 months.

关 键 词：嗜酸性蜂窝织炎 

分 类 号：R632.4[医药卫生—外科学]