猪脾脏转移因子壳聚糖-海藻酸钠微囊的制备及其性能  

Preparation and Characterization of Alginate-Chitosan Microcapsules Loaded with Pig Spleen Transfer Factor

作　　者：唐文[1,2] 周凤[1] 姜彪[1] 付强[1] 张伟[1] 符华林[1,2] 

机构地区：[1]四川农业大学动物医学院 [2]动物疫病与人类健康四川省重点实验室,四川雅安625014

出　　处：《过程工程学报》2011年第4期660-665,共6页The Chinese Journal of Process Engineering

基　　金：教育部"长江学者和创新团队发展计划"创新团队项目(IRT0848)

摘　　要：以壳聚糖-海藻酸钠为囊材,采用乳化-外部凝胶法制备猪脾脏转移因子壳聚糖-海藻酸钠微囊,并研究了其粒径、载药量、包封率、体外释药等性质.结果表明,经优化工艺所制微囊球形度良好,平均粒径11.05μm,平均载药量11.60mg/g,平均包封率60.8%,在磷酸缓冲液(pH=7.4)中的释药曲线方程为ln(1-Q)=-0.0692t-0.6449(R2=0.9876),符合一级动力学方程.该制备工艺简单,所制猪脾脏转移因子微囊具有良好的溶胀性能和缓释性能.The microcapsules carrying pig spleen transfer factor were prepared by emulsion external gelatification method in an emulsion system with chitosan and alginate. Their characterization in diameter, loading rate, encapsulation efficiency, accumulative release in vitro and some other properties were studied. The results show that the microcapsules prepared based on the optimized formulation were sphere-like with the average diameter 11.05 /.tin, the loading rate was 11.60 mg/g, the encapsulation efficiency was 60.8%, and the accumulative release curve in vitro at pH 7.4 was fitted to first order kinetics equation, ln（1-Q）=-0.0692t-0.6449 （R2=0.9876）. The preparation procedure is simple, and the microcapsules possess excellent sustained release and swelling behavior.

关 键 词：转移因子 乳化-外部凝胶法 海藻酸钠 壳聚糖 微囊 

分 类 号：R979.5[医药卫生—药品]