胃癌患者血清中巨噬细胞抑制因子-1的临床价值研究  

Application of serum macrophage inhibitory cytokine-1 in gastric cancer

作　　者：王小兵[1] 付超[2] 田海梅[1] 李艳芬[1] 李茉[1] 程冬婉[1] 常青云[1] 刘珊[1] 齐军[2] 张伟 

机构地区：[1]中国医学科学院北京协和医学院肿瘤医院生物检测中心,北京100021 [2]中国医学科学院北京协和医学院肿瘤医院检验科,北京100021

出　　处：《癌症进展》2011年第4期379-383,共5页Oncology Progress

基　　金：国家高技术研究发展863计划资助项目(项目编号:2008AA02Z415)

摘　　要：目的探讨巨噬细胞抑制因子1(MIC-1)在胃癌诊断、治疗监测及复发预警中的临床价值。方法应用自主研制的MIC-1检测试剂盒检测179例不同临床分期的胃癌患者、9例胃部良性疾病患者及200例健康人群血清样本中MIC-1水平,并对部分肿瘤患者进行动态监测;同时应用罗氏Cobas 601电化学发光免疫分析仪检测上述样品的CEA和CA19-9水平,并与MIC-1检测结果进行比较。结果胃癌患者组MIC-1血清水平显著高于良性疾病组和正常对照(951.68±785.40,532.92±222.16,391.56±299.55,P<0.001);MIC-1在早期胃癌患者(Ⅰ期和Ⅱ期)中显示出良好的诊断敏感性,远优于CEA和CA19-9(Ⅰ期:28.6%、8.6%、5.7%;Ⅱ期:37.8%、17.8%、0%);MIC-1、CEA和CA19-9联合检测,可由原来CEA18.4%和CA19-9 10.0%的灵敏度提高至52.0%,显著优于MIC-1、CEA和CA19-9单独检测;MIC-1血清水平在有效治疗后显著下降(P=0.004),复发转移时MIC-1水平显著升高(P=0.002)。结论研究结果明确显示MIC-1是胃癌有效的新血清肿瘤生物标志物,对于提高胃癌的诊断和早期诊断水平以及评价临床疗效具有重要的临床意义和价值。Objective To investigate the clinical value of macrophage inhibitory cytokine-1 （ MIC-1 ） in diagnosis, early diagnosis, treatment monitoring and recurrence warning of gastric cancer. Methods Serum samples form179 pa- tients with stages of gastric cancer, 9 patients with gastric benign diseases and 200 healthy persons （as were detected by MIC-1 assay kit for MIC-] level. And some of tumor patients were followed up. CEA and CA19-9 were tested by Roche Cobas 60l ECL analyzer. Results MIC-1 level in gastric cancer patients was significantly higher than that in benign dis- ease patients and normal persons （951.68 ±785.40, 532. 92 ±222. 16, 391.56 ±299.55, P 〈 0. 001 ）. MIC-I have more sensitivity than CEA and CA19-9 in patients with early gastric cancer （stage Ⅰ ： 28.6% , 8.6% and 5.7% ; stageⅡ ： 37. 8%, 17. 8% and 0% ）. Combined detection of CEA, CA19-9 and MIC-I increased the sensitivity from 18.4% of CEA, 10. 1% of CA19-9 to 52. 0%, which was significantly better than the detection of MIC-1, CEA and CA19-9 a- lone. MIC-1 level decreased significantly after effective treatment （P =0. 004）, and significantly increased at recurrence （P =l）. 002）. Conclusion MIC-1 is a new and effective gastric cancer biomarker in serum for the diagnosis of gastric cancer. It has important clinical value in improving early diagnosis and monitoring clinieal response.

关 键 词：巨噬细胞抑制因子-1 肿瘤标志物 胃癌 临床价值 

分 类 号：R392-33[医药卫生—免疫学]