量子点脂质体技术的应用进展  

Application progress of quantum dot-liposomes

作　　者：于杰[1,2] 叶超[1,2] 李臣贵[1,2] 陈蓉[1,2] 胡育筑[1,2] 

机构地区：[1]中国药科大学分析化学教研室 [2]药物质量与安全预警教育部重点实验室,南京210009

出　　处：《中国药科大学学报》2011年第4期380-384,共5页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.30873197)~~

摘　　要：量子点作为一类新型无机纳米荧光探针,其在体内外荧光成像和检测中具有突出优势。基于量子点的光学特性及荧光成像技术,将量子点与脂质体结合,改善了量子点的生物相容性,降低其原有的生物毒性,使其在生物医药领域得到更加广泛的应用。本文结合量子点脂质体的特征与表征方法,综述了其在肿瘤细胞靶向标记、活体成像以及药物在体内外转运、释放监测等方面的应用。Quantum dots have proven themselves as powerful inorganic fluorescent probes,especially for imaging and detection in vivo and in vitro.Moreover,based on the advantages of quantum dots,some researchers encapsu-lated quantum dots with liposomes.Compared with the unencapsulated quantum dots,the quantum dot-liposomes have a better biocompatibility and lower toxicity.In this review,combining with the advantages of quantum dot-liposome and the characterization,the recent applications of quantum dot-liposome,such as tumor cell targeting,in vivo imaging and the transportation of drugs in vivo and in vitro were summarized.

关 键 词：量子点脂质体 肿瘤细胞靶向标记 活体成像 药物释放 

分 类 号：R944[医药卫生—药剂学]