哮喘患儿变应原特异性免疫球蛋白E与总免疫球蛋白E相关性研究  

Relationship between total and specific IgE in patients with asthma

作　　者：王伟[1] 王芳[1] 刘哲伟[1] 

机构地区：[1]首都儿科研究所,北京100045

出　　处：《中国实用儿科杂志》2011年第8期600-602,共3页Chinese Journal of Practical Pediatrics

摘　　要：目的探讨哮喘患儿血清总免疫球蛋白E(IgE)及特异性免疫球蛋白E(SIgE)之间的关系,验证血清总IgE(TIgE)水平是否直接依赖于环境中占优势的变应原所诱导的SIgE(SIgE)升高而升高的观点。方法收集2007年1月至2010年6月首都儿科研究所附属北京儿童医院门诊及住院的哮喘、咳嗽变异性哮喘(CVA)患儿219例,年龄3～16岁,平均(6.5±3.3)岁;其中男165例,女54例。应用荧光酶联免疫方法,进行混合真菌(mx1)、粉尘螨(d1)、户尘螨(d2)、猫毛(e1)、狗毛(e5)、艾蒿(w6)血清SIgE抗体和TIgE的测定。结果 219例患儿中SIgE阳性率分别是mx1:45.7%、d1:32%、d2:31.5%、e1:25.1%、e5:18.7%、w6:21.5%,中重度患儿的SIgE(≥50U/mL)阳性比率是mx1:14.16%、d1:12.79%、d2:15.53%、e1:8.22%、e5:1.14%、w6:2.74%,(1)mx1、d1、d2、e1、e5、w6血清SIgE抗体对TIgE的升高有显著意义,均为(r=0.000,P<0.01)。(2)本值是以200为分界值,以TIgE≥200U/mL的病例为一组值进行分析,在TIgE≥200U/mL者中特异性e1及特异性e5IgE抗体明显导致TIgE的升高(P<0.01),而d2、d1、w6与高TIgE无相关性(P>0.01)。结论环境中占优势的过敏原并不都是可以导致较高的TIgE水平。Objective To investigate the relationship between total immunoglobulin E （tlgE） and specific immunoglob- ulin E （sIgE） in serum, and verify whether the elevation of serum tlgE directly depends on increasing slgE against the dominant allergen in the environment. Methods Totally 219 oat-patients or in-patients with asthma or cough variant asthma（CVA） were selected randomly in our hospital from January 2007 to June 2010. There were165 male and 54 female patients, with age ranging from 3 to 16 （mean ： 6.5）. With blood samples, tlgE and slgE directly against mixed moltls （mxl）, tlermatopbagoirles pternonyssinus （dl）, ttermawpbagoides farinae （d2）, cat （e1）, dog （e5）, anti artemisia vulgaris （w6） respectively were assayed by fluoroenzyme-lmmunometric assay, UniCAP100. Results We observed that in 219 patients, sIgE positive rates were 45.7% for mxl, 32% for d l, 31.5% for d2,25.1% for el, 18.7% for e5 and 21.5% for w6, respectively. （1） The elevation of tlgE was highly related to sIgE directly against mxl, d1, d2, el, e5 and w6 re- spectively （t = 0.000, P 〈 0.01 ）. （2） When tlgE was more than 200 U/mL, we observed that sIgE could lead to tIgE increasing significantly in cl an e5 group （P 〈 0.01 ）, but not in d2,d2 and w6 （P 〉 0.01 ）. Conclusion It is not a universal phenomenon that the dominant allergen in the environment could lead to tIgE increasing strongly.

关 键 词：哮喘 咳嗽变异性哮喘 变应原 血清免疫球蛋白E 

分 类 号：R72[医药卫生—儿科]