茱萸丸对大鼠实验性2型糖尿病的治疗作用  

Therapeutical Effect of Zhuyu Wan on Type 2 Diabetes in Rats

作　　者：刘瑞丰[1] 吕建东[1] 张晓鹏[1] 喇孝瑾[1] 王亚[1] 陈贵良[1] 殷华[1] 喇万英[1] 

机构地区：[1]河北联合大学中医学院,河北唐山063000

出　　处：《中国实验方剂学杂志》2011年第17期154-157,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技部国际合作项目(2008DFA31050)

摘　　要：目的:观察茱萸丸对实验性2型糖尿病大鼠降糖、降脂等作用的影响。方法:Wistar大鼠110只,随机抽取50只作为正常大鼠实验组,其余60只为糖尿病大鼠组。糖尿病组以高脂饲料诱导加链脲佐菌素(STZ)30 mg.kg-1 ip建立2型糖尿病模型,7 d后选取成模大鼠50只。50只正常大鼠和50只糖尿病大鼠各自按随机数字表法分为正常组(0.9%生理盐水)、模型组(0.9%生理盐水)、药物组(盐酸二甲双胍0.2 g.kg-1)、茱萸丸组(低、中、高剂量组分别为0.75,1.5,3 g.kg-1),每组10只。连续ig给药2周后,观察各组大鼠体重、血糖、血脂的变化。结果:茱萸丸对实验性2型糖尿病大鼠血糖有明显降低作用(P<0.01),对正常大鼠血糖无明显变化;能明显改善糖尿病大鼠的血脂(P<0.01),明显降低大鼠TC,TG,对糖尿病大鼠治疗后期的体重减轻起到延缓的作用(P<0.01)。结论:茱萸丸能降低糖尿病大鼠的血糖,改善糖尿病大鼠的血脂和体重。Objective：To observe the hypoglycemic and hypolipemic effects of Zhuyu Wan on experimental type 2 diabetes in rats.Method： One hundred and ten Wistar rats were divided randomly into normal experimental group（50 rats）,and diabetes experimental group（60 rats）.The type 2 diabetic model was established through high fat diet and administration of Streptozotocin（30 mg·kg-1 ip）.After 7 days,50 rats were selected from the diabetes group.The selected 50 diabetic rats were randomly divided intothe following groups：model group（ig normal saline）,metformin group（ig metformin hydrochloride 0.2 g·kg-1）,three Zhuyu Wan groups（ig 0.75,1.5,3 g·kg-1 accordingly）.Another 50 normal rats were divided similarly as the above diabetic rats,except the model group was replaced by a normal control group.All the rats were treated accordingly for two weeks.Then,effectiveness was evaluated by determinations of body weight,blood glucose and blood lipid.Result：Zhuyu Wan showed an obvious effect on lowering the blood glucose level in type 2 diabetes rats（P0.01）,but it had no distinct effect on the blood glucose level for the normal rats.Zhuyu Wan could improve glucose obviously（P0.01）,decrease the index on TC and TG,and delay the weight loss in diabetic rats（P0.01）.Conclusion： Zhuyu Wan can lower blood glucose,and regulate blood lipid and weight loss in type 2 diabetic rats.

关 键 词：茱萸丸 实验性2型糖尿病 大鼠 降糖 降脂 二甲双胍 

分 类 号：R285.5[医药卫生—中药学]