促愈颗粒对乙酸胃溃疡大鼠血清一氧化氮、胃泌素和血浆神经降压素的影响  

The effects of Cuyu Granule on Nitric Oxide,Gastrin in Serum and Plasma Neurotensin in Rats with Gastric Ulcer Induced by Acetic Acid

作　　者：冯云霞[1] 时昭红[1] 张介眉[1] 郝建军[1] 张书[1] 闻海军 

机构地区：[1]武汉市第一医院,武汉430022 [2]英山县人民医院中医科,黄冈436700

出　　处：《中国实验方剂学杂志》2011年第17期181-184,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：武汉市临床医学科研项目(武卫[2007]43号)

摘　　要：目的:探讨促愈颗粒对乙酸胃溃疡(GU)大鼠血清一氧化氮(NO)、胃泌素(Gas)和血浆神经降压素(NT)的影响。方法:用乙酸制备大鼠胃溃疡模型,随机分为正常对照组、模型组、促愈颗粒组(28.8 g.kg-1)和雷尼替丁组(27 mg.kg-1)。pH计测量胃液酸度,硝酸还原法检测血清NO的水平,放免法检测血清Gas,血浆NT含量。结果:与模型组相比,促愈颗粒使GU大鼠胃液pH值和血清Gas,NO含量显著增高水平显著增高(P<0.05),血浆NT含量显著降低(P<0.05);与雷尼替丁组相比,促愈颗粒组胃液pH值、血清Gas含量、血浆NT含量均无明显差异。但NO水平明显增高(P<0.05)。结论:促愈颗粒能提高再生黏膜质量,提高胃液pH值,调节NO,Gas,NT是其作用机制。Objective：To investigate the effect of Cuyu granule on the nitric oxide（NO）,gastrin（GAS） in serum and neurotensin（NT） in blood plasma in rats with gastric ulcer induced by acetic acid.Method： The rats were randomly divided into four groups：control group,model group,Cuyu granule（28.8 g·kg-1）group and Ranitidine（27 mg·kg-1）group.The rat model of gastric ulcer was induced by acetic acid.The pH meter was used to measure the pH of stomach liquid.The content of gastrin in serum and NT in blood plasma were detected with radio immunoassay.The level of NO in serum was determined by the method of nitric acid reductase.Result： Compared with model group,the pH of stomach liquid,the contents of gastrin and NO in Cuyu granule group were increased as NT in blood plasma decreased significantly（P0.05）.Compared with ranitidine group,the pH of stomach liquid,the content of gastrin in serum and NT in blood plasma of Cuyu granule group showed no differences,but the level of NO in serum was increased significantly（P0.05）.Conclusion： Cuyu granule can ameliorate the quality of reborn mucosa and increase pHin treatment of gastric ulcer.The mechanism may be related to regulation of NO,Gas and NT.

关 键 词：胃溃疡 促愈颗粒 胃肠激素 

分 类 号：R285.5[医药卫生—中药学]