昆布多糖硫酸酯对荷瘤小鼠前列腺癌的抑瘤作用  

Inhibitory Effect of LAMS Against Prostatic Cancer in Tumor-earing Mice

作　　者：邹明畅[1] 盛玉青[1] 崔飞伦[1] 

机构地区：[1]镇江市第一人民医院,江苏镇江212002

出　　处：《中国实验方剂学杂志》2011年第17期223-225,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：镇江市科学技术局项目(SH2007027)

摘　　要：目的:研究昆布多糖硫酸酯(LAMS)对移植前列腺癌细胞RM-1荷瘤小鼠的抑瘤作用。方法:C57小鼠接种前列腺癌RM-1细胞7 d后,按瘤体大小将40只小鼠均分为4组,分别为模型组(NS),环磷酰胺(CY)组(20 mg.kg-1),LAMS低、高剂量组(50,100 mg.kg-1)i,g,1次/d,连续14 d,停药次日称体质量并处死动物,剥取瘤块,摘取脾脏和胸腺,称质量,计算抑瘤率、脾指数和胸腺指数。结果:CY 20 mg.kg-1抑瘤率为40.3%,LAMS低、高剂量组抑瘤率分别为25.0%和33.8%,与模型组比较均有显著差异;CY在抑瘤的同时能显著抑制荷瘤小鼠的胸腺指数和脾指数,与模型组比较有显著性差异,LAMS对荷瘤小鼠的胸腺指数和脾指数无明显影响。结论:LAMS对移植前列腺癌RM-1的荷瘤小鼠有一定的抑瘤作用,LAMS在抑制肿瘤的同时不影响荷瘤鼠的免疫功能,无CY等化疗药物的常见副作用。Objective：To study the inhibitory effect of LAMS on prostatic cancer growth in tumor-bearing mice.Method：Fourty C57 mice inoculated with RM-1 prostate cancer cells for 7 days were divided into 4 groups according to the tumor size：the model group（NS）,cyclophosphamide（CY） group（20 mg·kg-1）,LAMS low and high dose groups（50,100 mg·kg-1）,ig,once daily.After 14 days of treatment,the animals were killed.The subcutaneous sarcoma,thymus and spleen were separated and weighted.Inhibition rate,spleen index and thymus index were then calculated.Result： CY 20 mg ·kg-1 significantly inhibited the growth of tumor,the inhibition rate was 40.3%;LAMS（low and high dose） also showed significant inhibitory effect compared with the model group,the inhibition rates were 25.0% and 33.8%.CY could significantly inhibited the thymus index and spleen index in tumor-bearing mice,however,the effects of LAMS were not significant.Conclusion：LAMS have inhibitory effects on RM-1 in tumor-bearing mice,but do not affect the immune function.Furthermore,LAMS has no side effects on chemotherapy drugs such as CY.

关 键 词：前列腺癌 昆布多糖硫酸酯 RM-1细胞 抑瘤率 胸腺指数 脾指数 

分 类 号：R285.5[医药卫生—中药学]