阿魏化学成分、药理作用及毒性研究进展  

Research Progress in Chemical Components,Pharmacological Effectiveness and Toxicity of Ferula assafoetid

作　　者：赵保胜[1] 桂海水[1] 朱寅荻[1] 徐暾海[1] 

机构地区：[1]北京中医药大学,北京100102

出　　处：《中国实验方剂学杂志》2011年第17期279-281,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(30772890)

摘　　要：目的:总结阿魏在化学成分、药理作用、毒理方面的研究进展,为阿魏合理开发提供参考。方法:查阅近些年有关阿魏在化学成分、药理作用、毒性等方面的文献、书籍,并对其进行汇总、分析、综述。结果:目前为止,已发现的化学成分主要有挥发油、香豆素和苯丙素类成分。药理研究表明,阿魏具有抗炎、抗过敏、抑制胃肠蠕动、抗氧化和杀菌等作用。结论:从文献来看,阿魏的研究主要在抗炎、抗氧化和胃肠道作用等方面,对其抗肿瘤作用药理研究较少,只有少数阿魏制剂在临床上用于抗肿瘤,建议加强阿魏抗肿瘤研究,以探讨其"消积"作用及其机制,为从现代药理学角度阐明阿魏功效奠定基础。Objective：To summarize the research progress on chemical components,pharmacological actions and toxicity of Ferula assafoetid,and provide useful references for the further research.Method： Literatures about F.assafoetid in plenty of journals and books were referred to,and the progress of the chemical components,pharmacological actions and toxicity were summarized.Result： Up to now,the chemical components isolated from F.assafoetid include mainly essential oil,coumarin,and phenylpropanoids.Pharmacological references show that it has anti-inflammation,anti-oxidation,inhibition of gastrointestinal motility and disinfection effect.Conclusion： The pharmacological research mainly focus on its antiinflammation,anti-oxidation and gastrointestinal effects,but very few researches focus on its anti-tumor effect,we should carry out further studies on mechanism-based anti-tumor activity,so that we may understand the effect and its pharmacological mechanism of ＂removing retention and stagnation＂,and establish groundwork for illuminating the effectiveness of F.assafoetid.

关 键 词：阿魏 化学成分 药理作用 研究进展 

分 类 号：R285.5[医药卫生—中药学]