二维核磁共振定域谱及其在活体中的应用  

Two-Dimensional Localized Magnetic Resonance Spectroscopy and its In Vivo Application

作　　者：王小红[1] 张钦塔[1] 林雁勤[1] 陈忠[1] 

机构地区：[1]厦门大学物理系,福建省等离子体与磁共振研究重点实验室,福建厦门361005

出　　处：《波谱学杂志》2011年第3期419-436,共18页Chinese Journal of Magnetic Resonance

基　　金：国家自然科学基金资助项目(10974164);中央高校基本科研业务费资助项目(2010121010)

摘　　要：核磁共振定域谱(MRS)是获得活体生化定量信息和诊断信息的无损检测技术,是核磁共振成像强有力的补充技术,可为临床诊断和疾病预测提供重要的信息.然而,活体1D1H MRS通常存在代谢物谱峰拥挤、分辨率较低和归属难等问题.引入2D MRS可在较大程度上解决1H MRS谱峰重叠和谱峰归属难的问题.该文简述和分析了几种典型的2D MRS新方法及其优缺点,并讨论了它们在脑部、肌肉、乳腺、前列腺等活体组织中的应用.虽然2DMRS存在着实验时间较长的局限,但最新研究表明其具有一些独特的优势及较好的发展前景.Localized magnetic resonance spectroscopy（MRS） is a non-invasive technique for acquiring in vivo biochemical and diagnostic information,acting as a powerful complement to MRI.It can provide important information for clinical diagnosis and disease prediction.However,1D in vivo 1H MRS has the problems of peak crowding,low spectral resolution and difficult peak identification.The two-dimensional（2D） MRS has been introduced to address these problems to a large extent.In this review,we analyzed the advantages and disadvantages of several typical 2D MRS methods.Their in vivo applications in brain,muscle,breast and prostates were also discussed.Although 2D MRS has the limitation of long experimental time,it still holds some unique advantages and presents a promising prospect according to the latest research.

关 键 词：核磁共振定域谱 二维谱 活体 分子间多量子相干 L-COSY 

分 类 号：O482.53[理学—固体物理]