血管生成素及其Tie-2受体与2型糖尿病视网膜病变的相关性研究  

Association of angiopoietins and soluble angiopoietin receptor Tie-2 with diabetic retinopathy in patients with type 2 diabetes

作　　者：尤巧英[1] 朱麒钱[1] 斯徐伟[1] 王兴木[2] 

机构地区：[1]绍兴市人民医院内分泌代谢科,312000 [2]绍兴市人民医院检验科,312000

出　　处：《中华内分泌代谢杂志》2011年第8期639-641,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：2型糖尿病增殖性视网膜病变（PDR）组血清血管生成素（Ang）2水平明显高于非增殖性视网膜病变组（NPDR）和2型糖尿病无视网膜病变组[分别为5．80（3．83—8．00）、4．42（2．56～5．55）和2．75（1．40—4．64）ng／ml，P〈0．01]，NPDR组高于2型糖尿病无视网膜病变组（P〈0．01）；Ang-1在NPDR组高于2型糖尿病无视网膜病变组[10．57（8．99—12．05）对9．21（7．71～11．2）ng／ml，P〈0．05]；Tie-2受体在3组间差异无显著性（P〉0．05）。提示血清Ang-2水平可能与2型糖尿病视网膜病变的严重程度相关。Angiopoietin-2 levels were5.80（3.83-8.00）, 4.42（2.56-5.55）, and 2.75（1.40-4.64） ng/ml in type 2 diabetic patients with proliferative retinopathy, patients with non-proliferative retinopathy, and patients without retinopathy, respectively. Statistical signifieances existed between any two groups （all P 〈 0.01 ）. Angiopoietin-1 level in patients with non-proliferative retinopathy was higher than that in patients without retinopathy [ 10. 57 （ 8.99-12. 05 ） vs 9.21 （7.71-11.2 ） ng/ml, P〈0. 05 ]. No difference in receptor Tie-2 was found among the 3 groups （P〉0. 05 ）. The results suggested that serum angiopoietin-2 level might be associated with the severity of retinopathy in type 2 diabetic patients.

关 键 词：血管生成素 受体 TIE-2 糖尿病 2型 视网膜病变 

分 类 号：R587.2[医药卫生—内分泌]