糖尿病患者血清可溶性血管内皮细胞钙黏蛋白水平与动脉粥样硬化关系的临床研究  

Correlation between serum vascular endothelial cells cadherin level and atherosclerosis in diabetic patients

作　　者：谢莹[1] 尤寿江[2] 严茹红[3] 曹勇军[2] 张艳林[2] 董吉祥[1] 刘春风[2] 

机构地区：[1]苏州大学附属第二医院内分泌科,215004 [2]苏州大学附属第二医院神经内科,215004 [3]苏州大学附属第二医院检验中心,215004

出　　处：《中华内分泌代谢杂志》2011年第8期641-643,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：研究糖尿病患者血清血管内皮细胞钙黏蛋白（VE—cadherin）、晚期糖基化终产物（AGE）与糖尿病大血管病变的关系。设健康对照组20例，糖尿病患者60例，其中伴颈动脉粥样硬化组30例，采用ELISA法测定各组血清可溶性VE—cadherin、AGE，并与病程、血糖水平进行多元逐步回归分析。糖尿病组与颈动脉粥样硬化组的VE-cadherin、AGE水平均高于对照组（均P〈0．05），糖尿病组与颈动脉粥样硬化组之间VE-cadherin差异有统计学意义（P〈0．05）。VE—cadherin水平与AGE显著正相关（r=0．69，P〈0．01），AGE与糖尿病病程呈正相关（r=0．31，P=0．02）。糖尿病患者血清中可溶性VE—cadherin水平与AGE相关，推测VE—cadherin可能是AGE致动脉粥样硬化的靶点和重要环节。To investigate the relationship among serum vascular endothelial cells （VE） -cadherin, advanced glycation end-products（ AGE）, and atherosclerotic lesion. 20 healthy subjects and 60 patients with diabetes mellitus, including 30 patients with carotid atherosclerosis （CI）, were enrolled. Soluble VE-cadherin and AGE were determined using the enzyme-linked immunosorbent method （ELISA）. The relationships among the concentration of soluble VE-cadherin, AGE, and the course of the disease, blood glucose, and blood lipid levels were analyzed with muhivariant stepwise regression analysis. The levels of serum VE-cadherin and AGE in the patients with diabetes and CI were higher than those in control group（ P〈0.05 ）. There was a significant difference in VE-cadherin between the diabetes group and the CI group（P〈0. 05 ）. Serum VE-cadherin levels were positively correlated with serum AGE levels（r = 0. 69, P 〈 0. 01 ）. AGE levels were positively correlated with the diabetes duration （ r = 0. 31, P = 0. 02）. The levels of serum VE-cadherin in diabetic patients are positively correlated with their serum AGE levels. The VE-cadherin seems to play an important role in the development of atherosclerosis caused by AGE.

关 键 词：血管内皮细胞钙黏蛋白 糖基化终产物 晚期 糖尿病 动脉粥样硬化 

分 类 号：R587.1[医药卫生—内分泌] R543.5[医药卫生—内科学]