我院289例外科围术期患者预防用抗菌药物调查分析  

Investigation and Analysis of 289 Cases of Perioperative Prophylactic Application of Antibiotics

作　　者：王雨波[1] 邹玉刚[1] 

机构地区：[1]遵义医学院第三附属医院药剂科,遵义市563002

出　　处：《中国药房》2011年第34期3190-3193,共4页China Pharmacy

摘　　要：目的:评价我院外科围术期患者预防用抗菌药物情况。方法:对我院2010年289例外科患者抗菌药物专项点评病例资料进行回顾性总结分析,从抗菌药物品种选择、用药时机、疗程、联合用药、费用等指标进行分析比较。结果:所调查289例患者中,抗菌药物预防性应用率为98.96%(286例);累计用药349次,平均每例患者应用1.21次;术前0.5～2h给药者120例(41.96%);抗菌药物平均疗程为7.02d;共涉及10大类35种,第1、2代头孢菌素,头霉素在Ⅰ、Ⅱ类切口手术中列前3位,应用频次列前3位的依次为头孢硫脒(61例/次)、头孢替唑(54例/次)、头孢美唑(36例/次);抗菌药物平均费用为1017.48元,占总住院费用的12.91%。结论:我院围术期患者预防用抗菌药物仍存在一定不规范性,需进一步采取相关措施加以干预。OBJECTIVE： To evaluate the perioperative prophylactic application of antibiotics in our hospital. METHODS ： Antibiotics evaluation medical records of 289 surgical patients in our hospital from Jan. to Dec. in 2010 were analyzed retrospectively in respect of selection of antibiotics, medication time, treatment course, drug combination and drug expenditure, etc. RESULTS： Among 289 patients, perioperative prophylactic application of antibiotics accounted for 98.96% （286 cases） with 349 times of drug use totally. The frequency of antibiotics use was 1.21 times. 120 cases （41.96%） received antibiotics 0.5-2 h before operation. Mean medication duration was 7.02 days. 10 categories and 35 kinds of antibiotics were used in perioperative period. The top 3 drugs for type I and Ⅱ incision operation were the first-generation and second-generation cephalosporins and cephamycins, and the top 3 drugs in the list of application frequency were cefathiamidine （61 cases/times）, ceftezole （54 cases/times）, cefmetazole （36 cases/times）. The average cost of antibiotics was 1 017.48 yuan, accounting for 12.91% of total hospital costs. CONCLUSIONS：Irrational use of perioperative prophylactic antibiotics is common and must be standardized with relevant measures.

关 键 词：围术期 抗菌药物 合理应用 

分 类 号：R969.3[医药卫生—药理学] R978.1[医药卫生—药学]