溪黄草的化学成分研究  

Studies on chemical constituents of Rabdosia serra

作　　者：郑琴[1,2] 崔炯谟[2] 傅宏征[1] 

机构地区：[1]北京大学天然药物及仿生药物国家重点实验室,北京100191 [2]延边大学药学院,吉林延吉133000

出　　处：《中国中药杂志》2011年第16期2203-2206,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30772639)

摘　　要：目的:对溪黄草的化学成分进行研究。方法:利用萃取,硅胶、凝胶和反相硅胶柱色谱以及高效液相色谱法进行分离和纯化,采用波谱学技术(1D和2D NMR,MS,IR等)进行结构鉴定。结果:分离并鉴定出6个化合物,分别是ent-1α,7α,14β,20-tetrahydroxy-11,16-kauradien-15-one(1),kamebakaurin(2),dihydrokamebakaurin(3),rabdoinflexin A(4),胡萝卜苷(5),β-谷甾醇(6)。结论:其中化合物1为新化合物,化合物3为首次从该植物中分离得到。Objective： To study the chemical constituents of aerial part of Rabdosia serra.Method： The compounds were isolated by extraction,coloum chromatography over silica gel and ODS,and preparative HPLC.Their structures were identified by various spectroscopic methods including MS,IR,1D and 2D NMR data.Result： Six compounds were isolated from R.serra and were characterized as ent-1ɑ,7ɑ,14β,20-tetrahydroxy-11,16-kauradien-15-one（1）,kamebakaurin（2）,dihydrokamebakaurin（3）,rabdoinflexin A（4）,daucosterol（5）,and β-sitosterol（6）.Conclusion： Compound 1 is a new compound,and coumpound 3 was obtained from this plant for the first time.

关 键 词：溪黄草 ent-1α 7α 14β 20-tetrahydroxy-11 16-kauradien-15-one 贝壳杉烷型二萜 

分 类 号：R284[医药卫生—中药学]