口服布洛芬治疗新生儿动脉导管未闭的临床应用  

Clinical applications of oral ibuprofen in neonatal with patent ductus arteriosus

作　　者：李奕婵[1] 曾虹[1] 李建东[1] 

机构地区：[1]南方医科大学附属潮州市中心医院,广东潮州521021

出　　处：《中外医学研究》2011年第24期55-56,共2页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的探讨口服布洛芬治疗新生儿动脉导管未闭(PDA)的临床价值及安全性。方法 2001年1月～2009年12月在本院新生儿科住院的高危新生儿,经彩色超声心动图检查确诊有PDA的58例新生儿进行回顾性分析,30例口服布洛芬进行治疗的为治疗组,28例未做治疗为对照组,观察两组PDA关闭情况并作对照分析。结果 30例PDA患儿经口服布洛芬治疗后23例闭合,6例未闭;28例未经药物治疗的PDA患儿,13例自然闭合,治疗组闭合率76.7%,对照组自闭率46.4%,治疗组闭合率高于对照组(P<0.05),且布洛芬治疗组患儿未发生消化道出血、黄疸、尿少等不良反应。结论口服布洛芬治疗新生儿PDA效果较好,不良反应少,可避免部分患儿以后手术的痛苦。Objective Explore oral ibuprofen neonatal artery catheter not closed treatment （PDA） and the clinical value of safety. Methods From January 2001 to December 2009 in our hospital in pediatrics new high - risk newborn, the color echocardiography established the PDA 58 newborns were analyzed retrospectively, 30 cases were treated by ibuprofen treatment for the treatment group, 28 cases do not treat as control group, observe two groups close status and PDA compared. Results 30 cases of children of the PDA by oral ibuprofen 23 cases closed after treatment, 6 patients not closed; 28 patients without drug treatment of children of the PDA, 13 cases, the treatment group natural closed closed 76.7% in the control group, the rate closed 46.4% rate, The treatment group closed rate is higher than the control group （P 〈 0. 05）, and ibuprofen of children of the treatment group did not happen gastrointestinal bleeding, jaundice, urine and less adverse reactions. Conclusion Oral Ibuprofen has better effect in treating neonatal with PDA and has few adverse effect, which can reduce suffering caused by operation on some infant patients.

关 键 词：布洛芬 新生儿 动脉导管未闭 

分 类 号：R725.4[医药卫生—儿科]