HPLC法测定阿奇霉素颗粒剂的溶出度  

Determination of dissolution of Azithromycin Granules

作　　者：殷召玲 房增龙 王晓梅 陶薇 

机构地区：[1]薛城区中医院,山东枣庄277100 [2]山亭区水泉乡卫生院,山东枣庄277100 [3]枣庄市药品检验所,山东枣庄277100 [4]枣庄海王药业连锁有限公司,山东枣庄277100

出　　处：《齐鲁药事》2011年第8期453-454,457,共3页qilu pharmaceutical affairs

摘　　要：目的建立阿奇霉素颗粒剂的溶出度测定方法。方法采用浆法,以磷酸盐缓冲液(pH6.0)为溶出介质,溶剂量500 mL,转速为100 r.min-1,溶出时间为30 min,用高效液相色谱法进行测定。结果本方法线性关系良好,平均回收率在99.9%,RSD=0.5%(n=9)。结论本方法简便、准确,可为阿奇霉素颗粒剂溶出度的测定提供依据。Objective To establish a determination method of dissolution of Azithromycin Granules. Methods Paddle method was adopted The 500 mL phosphate buffer （ pH 6.0 ） were used as dissolution medium which the speed was set at 50 r. min^-1. The dissolution time was 30 min and then were determined by HPLC. Results The linear relationship was good with average revocery of 99.9% （ RSD = 0. 5 %, n = 9 ）. Conclusion The method was simple and accurate, can provide the basis for the determination of dissolution of Azithromycin Granules.

关 键 词：阿奇霉素颗粒剂 溶出度 高效液相色谱法 

分 类 号：R927.11[医药卫生—药学]