有序电纺纤维膜的制备方法及在组织工程中的应用进展  

Preparation of Aligned Electrospun Fibrous Membranes and Their Applications in Tissue Engineering

作　　者：郑鑫[1] 廖桂英[1,2] 仰大勇[3] 解孝林[2] 

机构地区：[1]中国地质大学材料科学与化学工程学院,湖北武汉430074 [2]华中科技大学化学与化工学院,湖北武汉430074 [3]中国科学院苏州纳米技术与纳米仿生研究所,江苏苏州215125

出　　处：《高分子材料科学与工程》2011年第8期181-184,共4页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(20904037;30700171);中央高校基本科研业务费专项基金(CUG090108)

摘　　要：静电纺丝是一种简单且有效的制备高分子微纳米纤维的方法。近年来,通过电纺装置的控制制备有序纤维膜已成为研究热点,由此构建的电纺纤维膜支架具有独特的结构和生物学性能,有利于细胞的粘附、增殖和分化,在神经、血管、骨与软骨等组织工程及组织修复中具有良好的应用前景。文中对有序电纺纤维膜的制备方法进行了总结,概述了有序电纺纤维膜在组织工程中的应用,并对有序电纺纤维膜的发展前景作出了展望。Electrospinning is a simple yet effective method for the preparation of polymer micro/nano-fiber.Recently,aligned electrospun fibrous membranes were fabricated by different methods,which has become the research hotspot.Specifically,aligned fibrous scaffold is beneficial to cell adhesion,proliferation and differentiation due to their unique micro/nano structure and biological properties.Electrospun fibrous scaffold,therefore,has been widely used in tissue engineering,for example,as the scaffolds for nerves,blood vessels,bone and cartilage.In this paper,we summarized the methods to prepare the aligned electrospun fibrous polymer membranes,and reviewed their applications in tissue engineering and tissue reparation.In addition,the development prospect of the aligned electrospun fibrous membranes was also proposed.

关 键 词：静电纺丝 有序纤维膜 组织工程 粘附 增殖 

分 类 号：TB383[一般工业技术—材料科学与工程]