肝癌腹水癌细胞、白细胞体外抗癌药物敏感相关性研究  

The study about the ralationship of anti-cancer drug sensitivity for heptoma cell and leukocyte

作　　者：栗群英[1] 彭燕[1] 江忠勇[1] 但刚[1] 龚杨彬[1] 熊杰[1] 

机构地区：[1]成都军区总医院检验科,四川成都610083

出　　处：《四川医学》2011年第8期1291-1292,共2页Sichuan Medical Journal

摘　　要：目的探讨6种抗癌药物对肝癌晚期患者腹水癌细胞、白细胞化疗药敏结果及临床个体选药中的意义。方法采用CCK-8法检测抗癌药物对细胞的抑制率。结果卡铂、顺铂、阿霉素对大部分肝癌晚期患者腹水中癌细胞的抑制率明显高于白细胞(P<0.05),而羟基喜树碱对个别患者的白细胞抑制率明显高于癌细胞(P<0.05),丝裂霉素、氟尿嘧啶对两种细胞抑制率差异无统计学意义(P>0.05)。结论通过体外对比6种抗癌药物对肝癌患者白细胞和癌细胞的抑制率,以减少白细胞杀伤作用和增强癌细胞抑制作用为条件,为肝癌晚期患者优化化疗方案,提高疗效,并为进一步的临床个体化用药的实现提供一定的实验数据。Objective To investigate the clinic significance of 6 species anti-cancer drug susceptibility of which carcinoma cells and leukocyte in hydrogaster of advanced hepatoma.Methods CCK-8 is used to examine the cells inhibition which induced by anti-cancer drugs.Results Inhibition of carcinoma cells from hydrogaster induced by carboplatin,cisplatin and adriamycin obviously stronger than leukocyte in many hepatoma（P0.05）,the opposite results examined in hydroxycamptothecine in individual patients（P0.05）,but the effection of mitomycin and fluorouracil on carcinoma cells and leukocyte was no difference（P0.05）.Conclusion To comparing the inhibition of 6 species anti-cancer drugs on carcinoma cells and leukocyte from advanced hepatoma,the high-performance anticancer drugs were determined as results of low toxicity for leukocyte and fetal for carcinoma cells.The study results will provide identify experiment data for optimizing chemotherapy plans and improving individual therapy popularizing clinic individual medication.

关 键 词：四甲基偶氮唑蓝比色法 癌细胞 白细胞 抗癌药敏 

分 类 号：R735.7[医药卫生—肿瘤]