骨形成蛋白介导的基因治疗研究进展  

Advances in Bone Morphogenetic Protein-Mediated Gene Therapy

作　　者：司晓辉 杨连君 冯志军[2] 刘艳琳 吕晶 张雪 

机构地区：[1]煤炭总医院病理科,北京100028 [2]白求恩国际和平医院骨科,石家庄050082

出　　处：《北京生物医学工程》2011年第4期425-430,共6页Beijing Biomedical Engineering

基　　金：中国博士后科学基金(1999-17)资助

摘　　要：基因治疗是指通过导入基因的功能片段改善机体生理状况或者治疗疾病。利用基因治疗可在骨缺损或骨折局部释放骨形成蛋白(bone morphogenetic proteins,BMP),并且无需异体载体,方法包括体内法和离体法。BMP基因治疗可以促进骨和软骨形成、脊柱融合、颌面骨和牙齿修复、肌腱韧带形成,此外对椎间盘退变性疾病也可采用BMP基因治疗。总之BMP基因治疗方法经济有效,是有前景的治疗手段。Gene therapy is a technique that draws on the introduction of new genes into cells for the purpose of treating disease by restoring or adding gene expression. Bone morphogenetic proteins （BMP） can be delivered in bone defect or fracture local site by means of gene therapy without using heterogeneous carrier. At present, there are two alternative approaches for gene therapy in vivo and ex vivo, which is useful in the healing of the bone and cartilage defect, spinal fusion, craniofacial and dental repair, tendon and ligament formation, and in the treatment of degenerative disc disease. In conclusion, BMP gene therapy is an efficient, economic and promising strategy.

关 键 词：骨形成蛋白 基因治疗 骨缺损 骨愈合 

分 类 号：R318[医药卫生—生物医学工程] R683[医药卫生—基础医学]