84例下呼吸道革兰阴性杆菌院内感染细菌学与临床分析  

Antibiotic resistance of gram-negative bacteria from 84 patients with hospital acquired lower respiratory tract infection

作　　者：徐圣葆[1] 段报喜 

机构地区：[1]安徽省立友谊医院呼吸内科,安徽合肥233011

出　　处：《安徽医药》2011年第8期1005-1006,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的分析我院革兰阴性杆菌院内下呼吸道感染患者的细菌和耐药性分布情况以及其临床资料,为合理使用抗生素提供依据。方法以84例痰培养革兰阴性杆菌阳性的院内下呼吸道感染患者为研究对象,对其临床及细菌学资料进行回顾性统计分析。结果革兰阴性杆菌院内下呼吸道感染中非发酵条件致病菌占55.94%,其中铜绿假单胞菌最为常见,占非发酵菌总数的30.95%。超广谱β-内酰胺酶(ESBLs)的发生与患者有无基础疾病、ICU病房入住、三代头孢、氟喹诺酮以及免疫抑制剂使用有关,并影响患者的预后。结论院内下呼吸道革兰阴性杆菌感染细菌耐药性较为严重,要严格掌握抗菌药物使用原则,根据药敏选用抗菌药物。Aim To investigate the distribution and drug resistance among gram-negative bacteria from patients with hospital acquired respiratory tract infection in our hospital.Methods The bacterial and clinical data of 84 patients with hospital acquired respiratory tract infections were retrospectively analysed using SPSS13.0 soft ware.Results Non-fermentative bacteria accounted for 55.94% of total gram-negative bacteria.The most common bacteria was pseudomonas aeruginosa accounting for 30.95% of total non-fermentative bacteria.The incidence of ESBLs（extended spectrum β-lactamdses） was associated with coexistence of basic diseases,hospitalization in ICU,the useof third generation cephalosporins,fluoroquinolones and immunosuppressants etc.Conclusion Drug resistance of hospital acquired gram-negative bacteria is common and the rational selection and use of antibiotics should be based on the result of bacteriological monitoring.

关 键 词：革兰阴性杆菌 耐药性 下呼吸道感染 

分 类 号：R446.5[医药卫生—诊断学]