清肺通络方对小儿支原体肺炎细胞因子的干预及疗效观察  

Study on therapeutic and intervention effect of Qingfeitongluo prescription on cytokines in patients with MP

作　　者：姜永红[1,2,3] 姜之炎[1,2,3] 叶飞[1] 吴文[1] 李文[1] 郭爱华[1] 徐彬彬[1] 马晶[1] 张婧延[1] 胡鹏[1] 石李[1] 

机构地区：[1]上海中医药大学附属龙华医院儿科,上海200032 [2]上海中医药大学 [3]上海市中医药研究院中医儿科研究所,上海200071

出　　处：《天津中医药》2011年第4期288-290,共3页Tianjin Journal of Traditional Chinese Medicine

基　　金：上海中医药大学科研发展基金资助项目(0935)

摘　　要：[目的]观察清肺通络方对小儿支原体肺炎(MP)的疗效及对血清干扰素-γ(IFN-γ)、白介素-4(IL-4)、白介素-17(IL-17)的影响。[方法]选取支原体肺炎患儿135例,随机分为对照组和治疗组,观察两组的疗效,治疗前后血清IFN-γI、L-4I、L-17的变化。[结果]治疗组总有效率为94.67%,明显高于单纯西药对照组(P<0.05)。肺炎支原体肺炎患儿较正常儿童血清IFN-γI、L-4I、L-17均升高I,L-4I、L-17的差异有统计学意义(P<0.01,)IFN-γ升高无统计学意义。治疗组治疗前后血清IL-4I、L-17含量显著降低(P<0.01)I,FN-γ降低无统计学意义;对照组治疗前后差异无统计学意义。[结论]清肺通络方联合阿奇霉素治疗MPP疗效可靠,其机制可能与调节免疫紊乱有关。[Objective] To observe the intervention and therapeutic effect of Qingfeitongluo prescription on serum IFN-γ,IL-4,IL-17 levels in patients with mycoplasma pneumonia（MP）.[Methods] 135 cases with MP children were randomly divided into control group and treatment group.The therapeutic effects were observed in these two groups and the changes of serum levels of IFN-γ,IL-4,IL-17 before and after treatment were determined.[Results] The total effective rate of the treatment group was 94.67%,which was significantly higher than the control group（P0.05）.Serum IFN-γ,IL-4,IL-17 levels were increased in MP children compared with normal children with significant difference in IL-4 and IL-17（P0.01）,with no difference in IFN-γ level.After treatment serum IFN-γ,IL-4,IL-17 levels were decreased in both groups without significant difference when compared with control group,while in the treatment group,serum IL-4,IL-17 levels were significantly decreased（P0.01） and decreasing trend in IFN-γ was noted but no significant difference could be seen.[Conclusion] Qingfeitongluo prescription combined with azithromycin to treat MPP had reliable efficacy,which may be related with the regulation of immune disorders.

关 键 词：清肺通络方 支原体肺炎 细胞因子 疗效 

分 类 号：R563.13[医药卫生—呼吸系统]