盐酸戊乙奎醚对诱导剂量顺式阿曲库铵起效及再次注药时间的影响  

Effects of penehyclidine hydrochloride on the onset time and re-injection time of induction dose of cisatracurium

作　　者：李旭[1] 董有静[1] 

机构地区：[1]中国医科大学附属盛京医院麻醉科,沈阳110004

出　　处：《实用药物与临床》2011年第4期271-273,共3页Practical Pharmacy and Clinical Remedies

基　　金：辽宁省教育厅科研项目计划(L2010700)

摘　　要：目的比较盐酸戊乙奎醚与阿托品术前用药对诱导剂量顺式阿曲库铵起效时间及再次注药时间的影响。方法选择30例ASAⅠ~Ⅱ级无神经肌肉疾患并拟在全麻下行择期手术的女性患者,随机分成盐酸戊乙奎醚组（Ⅰ组,15例）和阿托品组（Ⅱ组,15例）。两组患者麻醉诱导前30 min分别肌注阿托品或盐酸戊乙奎醚0.01 mg/kg,采用TOF刺激方式,持续监测拇内收肌的收缩反应,TOF≥25%时追加肌松药,记录两组患者神经肌肉阻滞的起效时间及T1从0恢复至25%的时间。应用静脉麻醉诱导,七氟烷吸入麻醉维持。结果与阿托品组比较,盐酸戊乙奎醚组肌松起效时间明显缩短（P〈0.05）,再次注药时间明显延长（P〈0.05）。结论术前肌注盐酸戊乙奎醚能明显缩短诱导剂量顺式阿曲库铵的起效时间,增加临床肌松维持时间,延长再次注药的时间。Objective To compare the effects of penehyclidine hydrochloride and atropine as premedication on the onset time and re-injection time of cisatracurium.Methods Thirty ASA Ⅰ-Ⅱ female adult patients without any neuromuscular disease who underwent elective surgery under general anesthesia were randomly allocated into two groups with fifteen patients each：GroupⅠ（penehyclidine hydrochloride group）and Group Ⅱ（atropine group）.All patients were given penehyclidine hydrochloride 0.01 mg/kg or atropine 0.01 mg/kg deltoid muscle im.The responses of patients to train-of-four（TOF）stimulation of ulnar nerve were monitored.The onset time of cisatracurium,the duration of neuromuscular blockade time from TOF ratio（T1/Tc）0 to 25% were recorded.Intravenous anesthesia was used for induction and sevoflurane inhalation anesthesia was used for maintenance.Results Compared with atropine,the onset time of cisatracurium of penehyclidine hydrochloride was significantly shorter（P〈0.05）,and the re-injection time was significantly longer（P〈0.05）.Conclusion The preoperative intramuscular injection of penehyclidine hydrochloride can significantly reduce the cisatracurium′s onset time,increase the clinical relaxant maintance time of muscle and prolong the time of cisatracurium re-injection.

关 键 词：神经肌肉阻滞 盐酸戊乙奎醚 顺式阿曲库铵 起效时间 再次注药时间 

分 类 号：R614[医药卫生—麻醉学]