金银花和干姜对小鼠的毒性研究  

Toxicity of honeysuckle and dry ginger on mice

作　　者：蒲含林[1] 姜华[1] 陈蓉蓉[1] 

机构地区：[1]广东省暨南大学生物工程研究所,广州510632

出　　处：《实用药物与临床》2011年第4期277-278,共2页Practical Pharmacy and Clinical Remedies

摘　　要：目的研究寒热属性不同的中药(金银花、干姜)对小鼠的毒性作用。方法将金银花、甘草和干姜的水溶液给予小鼠2周,观察小鼠的生存情况,统计存活小鼠的数量。处死动物,取肝脏、肾脏和心脏组织,测定其中部分元素(锰、铁、铜、锌、镁、钙、磷)的含量变化。结果寒热属性不同的中药对实验动物的毒性作用非常明显,实验小鼠的肝脏、肾脏和心脏组织中,部分元素的含量出现了一定程度的变化,发生在肝脏组织中的元素含量变化最为显著。结论寒热属性不同的中药对小鼠有毒性作用,实验动物的肝脏组织可能是研究不同中药药性的较好的实验材料。Objective To study the toxicity of Chinese traditional medicine with different nature properties（honeysuckle and dry ginger）on tissues of mice.Methods After giving water solution of honeysuckle,dry ginger and liquorice for two weeks,the survival rates of mice in each group were recorded,the liver,kidney and heart tissues were separated,the contents of some elements of these tissues（including：manganese,iron,cuprum,zinc,magnesium,calcium,phosphorus）were assayed.Results The contents of some element in the liver,kidney and heart tissues of mice had changed in some extend,the change of liver tissue was most remarkable.Conclusion Chinese traditional medicine with different nature properties have certain toxicity on mice,the liver tissue of the experimental animal may be better experimental material to study the nature property of Chinese traditional drug.

关 键 词：金银花 干姜 元素含量 毒性 

分 类 号：R285.5[医药卫生—中药学]