磷酸肌酸钠对劳力型心绞痛患者PCI术心肌损伤的干预  

Intervention of phosphocreatinase to myocardial damage after PCI in patients with effort angina

作　　者：王静[1,2] 熊永红[2] 惠永明 周玉杰[1] 杨士伟[1] 王晶哲[1] 

机构地区：[1]首都医科大学附属北京安贞医院,北京100029 [2]北京丰台医院

出　　处：《中国循证心血管医学杂志》2011年第3期183-185,188,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的评价外源性补充磷酸肌酸钠对经皮冠状动脉介入治疗(PCI)术心肌损伤的影响。方法选择住院并接受PCI治疗的劳力型心绞痛患者206例作为研究对象,随机分为2组,每组103例。对照组采用指南推荐的常规治疗方案,试验组患者在常规治疗的基础上术后即刻给予磷酸肌酸钠静脉滴注,每次2g,2次/日,连续应用3d。所有患者术前及术后3d(磷酸肌酸钠疗程结束)检测酸磷酸激酶同工酶MB(CK-MB)和肌钙蛋白I(TnI)浓度。结果 PCI术后对照组较试验组患者CK-MB(82.1±59.0vs.55.4±40.8U/L,P=0.01)及TnI水平(0.483±0.402vs.0.388±0.415ng/ml,P=0.02)均显著增高。结论劳力型心绞痛患者PCI术后即刻给予外源性磷酸肌酸有助于减轻心肌损伤。Objective To review the influence of exogenous phosphocreatinase on myocardial damage after percutaneous coronary intervention（PCI）.Methods The patients with effort angina（n=206） accepted PCI were chosen and randomly divided into two groups（each n=103）.The control group was given routine treatment and experimental group,intravenous drip of phosphocreatinase（2 g once and twice a day for 3 days） besides of routine treatment immediately after PCI.The concentration of creatin kinase MB（CK-MB） and treponin I（TnI） were detected in all patients before PCI and 3 days after PCI and the treatment of phosphocreatinase were finished.Results The concentration of CK-MB（82.1±59.0 U/L vs.55.4±40.8 U/L,P=0.01） and TnI（0.483±0.402 μg/ml vs.0.388±0.415 μg/ml,P=0.02） increased significantly in the experimental group compared with the control group after PCI.Conclusion The immediate exogenous phosphocreatinase given to the patients with effort angina can abate myocardial damage after PCI.

关 键 词：磷酸肌酸 经皮冠状动脉介入术 冠状动脉疾病 心肌损伤 

分 类 号：R541.4[医药卫生—心血管疾病]