血清转化生长因子β_1与海拔高度及冠心病的相关性研究  

Correlation between serum level of transformation growth factor β_1 and altitude or coronary heart disease in people groups from high altitude area

作　　者：柳茵[1] 赵笑春[2] 朱斌[3] 

机构地区：[1]青海大学附属医院心内科青海省心血管病研究室,西宁810001 [2]北京同仁医院心内科 [3]青海大学附属医院心内科

出　　处：《中国循证心血管医学杂志》2011年第3期204-206,210,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探讨血清转化生长因子β1(TGF-β1)水平与海拔高度及冠心病的关系。方法健康体检人群一组为西宁地区人群(海拔:2260m)60例,其中蒙古族20例,汉族40例;另一组为高海拔地区(海拔:2800～3700m),其中蒙古族40例,汉族20例;青海大学附属医院心内科住院怀疑为冠心病的患者87例,其中经冠状动脉造影确诊冠心病组患者72例,其余15例作为对照组。采用酶联免疫吸附法检测受试者血清TGF-β1含量,同时检测受试者血脂及C反应蛋白(CRP)水平,对TGF-β1、血脂、CRP水平进行组间比较分析。结果高海拔地区健康人群血清中TGF-β1水平高于西宁地区健康人群,差异有显著统计学意义(P<0.01)。冠心病患者冠状动脉单支、双支、三支血管病变组随冠脉病变支数增加,血清TGF-β1水平呈降低趋势,且均低于对照组,双支病变组、三支病变组与对照组TGF-β1水平的差异具有统计学意义(P均<0.05);三支病变组患者血清TGF-β1低于单支病变组及双支病变组,差异有统计学意义(P<0.05);而单支病变组与双支病变组血清TGF-β1水平差异无统计学意义(P均>0.05)。冠心病各组与对照组及冠心病各组间CRP水平均无统计学差异(P>0.05)。结论高原地区健康人群TGF-β1水平增高,冠心病患者随冠脉病变支数增加而TGF-β1水平呈降低趋势。Objective To investigate the relationship between the serum level of transformation growth factor β1（TGF-β1） and altitude or coronary heart disease（CHD） in different people groups from high altitude area.Methods One health people group was from Xining（altitude：2260 m,n=60）,including 40 Mongolian subjects and 20 Han subjects.Another one health people group was from high altitude area（altitude：2800-3700 m,n=60）,including 40 Mongolian subjects and 20 Han subjects.The patients with suspected CHD（n=87） hospitalized in the Department of Cardiology of Affiliated Hospital of Qinghai University were chosen,and among them 72 were diagnosed by coronary angiography taken as the CHD group and other 15 taken as the control group.The level of serum TGF-β1 was detected by using enzyme-linked immunosorbent assay,and at the same time,the levels of blood fat and C-reactive protein（CRP） were detected.The levels of TGF-β1,blood fat and CRP were compared and analysed between two groups.Results The level of TGF-β1 was higher in the health people group from high altitude area than that in the health people group from Xining（P0.01）.The lever of serum TGF-β1 showed a decrease trend as the number of narrow vessels increased in the CHD patients with single vessel stenosis,2 vessel stenosis or 3 vesssel stenosis,and lower than that in the control group.The level of serum TGF-β1 was lower in the CHD patients with 3 vessel stenosis than that in the those with single vessel stenosis and 2 vessel stenosis（P0.05）.The level of serum TGF-β1 had no statistical difference（all P0.05） between the CHD patients with single vessel stenosis and those with 2 vessel stenosis.The level of CRP had no statistical difference（P0.05） between the CHD group and control group,and between different CHD groups.Conclusion The level of TGF-β1 increases in the health people group from high altitude area,and that in the CHD patients decreases as the number of narrow vessels increases.

关 键 词：转化生长因子Β1 海拔 冠心病 C-反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]