异槲皮苷抗抑郁作用实验研究  

Experimental study on the antidepressant activities of Isoquercitrin

作　　者：张利斌[1] 张晓庆[1,2] 李玉平[1] 

机构地区：[1]同济大学附属上海市肺科医院药剂科,上海200433 [2]上海交通大学附属第一人民医院药剂科,上海200080

出　　处：《药学实践杂志》2011年第4期272-273,290,共3页Journal of Pharmaceutical Practice

摘　　要：目的研究异槲皮苷对抑郁症模型小鼠的的抗抑郁活性。方法 ICR小鼠,随机分为空白模型组、阳性对照(盐酸氟西汀)组、异槲皮苷不同剂量组和10%异槲皮苷混合物不同剂量组,观察异槲皮苷对小鼠强迫游泳实验和小鼠悬尾实验的影响。结果与模型组相比,0.3 mg/kg槲皮苷和3 mg/kg10%异槲皮苷混合物能显著缩短小鼠在绝望模型中的不动时间(P<0.01)。结论低剂量的异槲皮苷具有一定的抗抑郁活性,其机制可能与异槲皮苷的抗氧化作用及抑制皮质激素分泌有关。Objective To study the antidepressant activities of Isoquercitrin on desperate rats model.Methods ICR Mice were randomly divided into control group,fluoxetine hydrochloride group,Isoquercitrin and Isoquercitrin mixture of different dose groups.The Frost Swimming Test（FST） and the Tail Suspension Test（TST） in mice were applied to evaluate antidepressant activitie.Results Compared with the control group,low dosages（0.3 mg/kg,3mg/kg） of Isoquercitrin and 10% Isoquercitrin mixture had significantly reduced the immobility time in the behavior tests（P0.01）.Conclusions Low dosage of Isoquercitrin showed some antidepressant activities,which was related to antioxidative effect and inhibiting of adrenocortical hormones.

关 键 词：异槲皮苷 抗抑郁 强迫游泳实验 悬尾实验 

分 类 号：R961[医药卫生—药理学]