HPLC法测定头孢曲松含量的不确定度评估  

Evaluation of measurement uncertainty method for determination of Ceftriaxone by HPLC

作　　者：杜珍[1] 

机构地区：[1]解放军海军总医院,北京100037

出　　处：《药学实践杂志》2011年第4期281-283,共3页Journal of Pharmaceutical Practice

摘　　要：目的对高效液相色谱法(HPLC)测定头孢曲松含量的测量不确定度进行评估。方法采用HPLC法测定头孢曲松的含量,建立数学模型,分析不确定度来源。结果通过对各变量的分析,计算各变量的不确定度,最后计算出合成标准不确定度。结论本方法建立的数学模型合理、可靠。Objective To evaluate the uncertainty of measurement for determination of Ceftriaxone by HPLC.Methods The content of Ceftriaxone was determined by HPLC.The mathematical model was established to analyze the source of uncertaint.Results Every component of uncertainty was evaluated through the variable parameters among the procedures.The combined standard uncertainty was finally obtained by synthesizing the uncertainties of all variables.Conclusion The statistical approach of measurement uncertainty established in this paper was reasonable and reliable.

关 键 词：高效液相色谱法 头孢曲松 测量不确定度 

分 类 号：R917[医药卫生—药物分析学]